Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India.
J Pediatr Endocrinol Metab. 2016 Nov 16. pii: /j/jpem.ahead-of-print/jpem-2016-0191/jpem-2016-0191.xml. doi: 10.1515/jpem-2016-0191. [Epub ahead of print]
Marwaha RK, Yenamandra VK, Ganie MA, Sethuraman G, Sreenivas V, Ramakrishnan L, Mathur SK, Sharma VK, Mithal A.
|60,000 IU Vitamin D |
monthly for 6 months
|Water-soluble in water||32 ng||100%|
|Fat-soluble in 4% milk||24 ng||83%|
- Note: The study does not indicate what % of the children who were lactose intolerant – which could have affected the results
Three out of four Indians have no milk tolerance: Study March 2015
- 28 liquid Vitamin D products have Micellization technology on Amazon as of Nov 2016
Up to 2,000 IU per drop
- Bio-Tech is the only company I am aware of that makes a non-liquid water-soluble form of vitamin D
- Vitamin D3 forms- powder best – April 2014
Which shows that the powder (which is water-soluble) form of Vitamin D is the most bio-available
The PDF ($42) indicates
- Only 50% of a typical dosage of vitamin D is absorbed from the intestine
Their reference for that statement happens to be in VitaminDWiki
Vitamin D bioavailability: State of the art – Oct 2014
Vitamin D deficiency is a widely recognized public health problem. Efficacy of a recently developed micellized form of vitamin D3 has not been studied. Hence, we undertook this study to compare its efficacy with the conventionally used fat-soluble vitamin D3.
In this open-labeled nonrandomized pilot study, we recruited 180 healthy children, aged 13-14 years in two groups and supplemented Group A (60 children) with 60,000 IU of fat-soluble vitamin D3/month with milk and Group B (120 children) with 60,000 IU/month of water miscible vitamin D3 under supervision for 6 months. Serum 25(OD)D, parathyroid hormone (PTH), calcium, phosphate, and alkaline phosphatase (ALP) levels were evaluated before and after supplementation in 156 children (54 in Group A and 102 in Group B ) who completed the study.
We observed a significantly greater increase in the serum 25(OH)D levels in group B as compared to group A (31.8±9.1 ng/mL vs. 23.7±10.4 ng/mL; p<0.001). All children in group B achieved adequate levels of serum 25(OH)D (>20 ng/mL) as against 83.3% children in group A. Serum PTH and ALP levels declined considerably in both the groups following supplementation.
Vitamin D supplementation significantly increased the serum 25(OH)D levels in both groups. Miscible form of vitamin D3 appears to be better in achieving higher levels of serum 25(OH)D than that observed with a similar dose of fat-soluble vitamin D3. Further studies with different dose regimens are required to establish its efficacy over the conventionally used fat-soluble vitamin D3.
PMID: 27849624 DOI: 10.1515/jpem-2016-0191