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Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017

Vitamin D Receptor Level in Biopsy Specimen of Patients with Ulcerative Colitis: Results from a Center in Western Anatolia

Journal of the National Medical Association, DOI: http://dx.doi.org/10.1016/j.jnma.2017.06.003

VitaminDWiki Summary

Patients with negative Vitamin D Receptor levels
UC 56%,   controls 10%

See also VitaminDWiki

Overview Gut and vitamin D contains the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
  • Many intervention clinical trials for vitamin D to prevent or treat Gut problems (93 trials listed as of Jan 2017)
  • All items in category gut and vitamin D 102 items

Gut category listing contains the following

102 items in GUT category - see also Overview Gut and vitamin D,


 Download the PDF from VitaminDWiki

Adil Coskun, M.D. M.D. Adil Coskun, M.D. Adil Coskun, Irfan Yavasoglu, M.D., Ibrahim Meteoglu, M.D., Mustafa Unubol, M.D., Burak Yasar, M.D., Serkan Borazan, M.D., Imran Kurt Omurlu, M.D., Vahit Yukselen, M.D., M. Hadi Yasa, M.D.

Background
Ulcerative colitis (UC) is a chronic, inflammatory bowel diseases characterized by uncontrolled inflammatory condition of the colon and rectal mucosa marked by recurrent periods of remission and exacerbation. Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. We aimed to evaluate vitamin d receptor level in biopsy specimen of patients with UC in this study.

Methods
VDR levels were retrospectively studied in colon biopsy specimens of UC patients. The Spearman's rho correlation analysis, The Kolmogorov–Smirnov, Mann Whitney U, and chi-square tests were used for statistical analysis. The p values below 0.05 were considered statistically significant.

Results
Study included 112 UC patients (65 male and 47 female) and 30 controls (19 female and 11 male) who had normal results in biopsy examinations carried out due to various reasons. VDR levels of UC patients were statistically lower than control subjects, and was not associated with duration of the disease and place of involvement.

Conclusions
VDR is an important receptor in the pathogenesis of UC, and optimizing vitamin D levels could have a therapeutic role in UC.

Created by admin. Last Modification: Monday July 3, 2017 16:08:52 UTC by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
8148 VDR UC.pdf PDF 2017 admin 03 Jul, 2017 15:59 604.46 Kb 23
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