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Type 1 diabetes strongly associated with low vitamin D – March 2013

The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus.

Int J Endocrinol. 2013;2013:148673. doi: 10.1155/2013/148673. Epub 2013 Mar 13.
Chakhtoura M, Azar ST.
Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York, NY 10017, USA.

The "nonclassic" role of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been recently widely recognized. In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role through the vitamin D receptor (VDR) present on pancreatic and immune cells. Specific VDR allelic variants have been associated with T1D in many countries. Furthermore, vitamin D deficiency has been prevalent in T1D, and the seasonal and latitude variability in the incidence of T1D can be partly explained by the related variability in vitamin D level. In fact, retrospective studies of vitamin D supplementation during pregnancy or infancy showed a lower incidence of T1D. We will review the different mechanisms of the vitamin D protective effect against insulitis and present the available data on the role of vitamin D deficiency in the control, progression, and complications of T1D.

PMID: 23573085

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INTERVENTION Clinical Trials for Type 1 Diabetes and Vitamin D 64 trials as of Dec 2014

Type 1 diabetes strongly associated with low vitamin D – March 2013

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- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014 Type 1 diabetes 3.5X more frequent if low vitamin D - Medscape CME Dec 2012 Type 1 Diabetes probability reduced by 2X if have more than 40 ng of vitamin D – Feb 2013 Type 1 diabetes strongly associated with low vitamin D – March 2013 Type 1 diabetes is increasing, vitamin D deficiency may be one of the reasons – Aug 2013 44 percent less Type 1 diabetes if high level of vitamin D – white skinned military – March 2013

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