Association of VDR polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis.
Endocr Connect. 2017 Feb 23. pii: EC-16-0110. doi: 10.1530/EC-16-0110. [Epub ahead of print]
Note: Increased Risk = 1.66 is buried deep inside of the PDF, it is highlighted in yellow
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
340 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
Pages listed in BOTH of the categories Diabetes and Vitamin D Receptor
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015
- Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
Vitamin D Receptor category has the following
Note that T2 diabetes has a similar increased risk
189 items in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 37 health problems click here for details
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:
Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) Magnesium Vitamin D in the blood
AND to the cells
3) Omega-3 Vitamin D to the cells 4) Resveratrol Vitamin D to the cells 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor
If poor Vitamin D Receptor
Health Problem 13 Sepsis 9.6 Chronic Periodontitis
7.6 Crohn's disease 5.8 Low back pain in athletes 5 Ulcerative Colitis 5 Coronary Artery Disease 4.6 Breast Cancer 4 polycystic ovary syndrome 3.3 Pre-term birth 3.1 Lumbar Disc Degeneration 3.1 Colon Cancer survival 3 Multiple Sclerosis 3 Dengue 3 Waist size 3 Ischemic Stroke 3 Alzheimer’s 2.8 Osteoporosis 2.7 Gastric Cancer 2.6 Lupus in children 2.4 Lung Cancer 2.3 Autism 2 Diabetic Retinopathy 2 Parkinson's 2 Wheezing/Asthma 2 Melanoma Non-melanoma Skin Cancers 2 Myopia 1.9 Uterine Fibroids 1.9 Early tooth decay 1.8 Diabetic nephropathy 1.6 Diabetes - Type I 1.6 Prostate Cancer while black 1.5 Diabetes -Type II 1.5 Pertusus 1.4 Rheumatoid arthritis 1.3 Childhood asthma 1.3 Tuberculosis
Sahin O1, Gökşen D2, Ozpinar A3, Serdar M4, Onay H5.
1O Sahin, Pediatrics, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey ozlemnaciyeatansahin at yahoo.com.
2D Gökşen, Department of Pediatric Endocrinology,, Ege University , Izmir, Turkey.
3A Ozpinar, Biochemistry, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey.
4M Serdar, Biochemistry, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey.
5H Onay, Department of Medical Genetics, Ege University Faculty of Medicine, Department of Medical Genetics, Izmir, 35100, Turkey.
There are studies evluating FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor gene and susceptibility to DM1 (type 1 diabetes mellitus) with controversial results. This present study aims to investigate the association between FokI, ApaI, TaqI and BsmI polymorphisms of vitamin D receptor (VDR) gene and DM1 in children.
A literature search was performed using Medline, EMBASE, Cochrane and Pubmed. Studies were included in the study if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined and outcome was DM1 at pediatric age. Data were pooled in a random effects logistic regression model and reported with 95% confidence intervals (95% CI).
A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the odds ratio value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB(P < 0.05), BsmIBb, (P < 0.05), BsmIbb(P < 0.05), TaqITT( P< 0.05) and TaqItt (P < 0.05) in children.
The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of DM1, while BsmIbb and TaqITT had protective effect for DM1 in children.
PMID: 28232367 DOI: 10.1530/EC-16-0110
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