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Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Genes 2017, 8(4), 125; doi:10.3390/genes8040125 (registering DOI)

VitaminDWiki
  • Vitamin D tests do not detect poor Vitamin D Receptor and 4 other classes of vitamin D genes.
  • Thus, you can have a good blood level of vitamin D but get T1 Diabetes and many other health problems because genes limit the amount of vitamin D getting to the cells
  • Health problems that run in families are often associated with low vitamin D - and genes decreasing Vitamin D getting to cells

Pages listed in BOTH of the categories Diabetes and Vitamin D Receptor

Vitamin D Receptor category has the following

143 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 29+ health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
13Sepsis
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
5.8Low back pain in athletes
5Coronary Artery Disease
4.6Breast Cancer
4PCOS
3.3 Pre-term birth
3.1Lumbar Disc Degeneration
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis if COPD
2.3Autism
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma
2Myopia
1.9Uterine Fibroids
1.6Type I Diabetes
1.6Prostate Cancer while black
1.5 Type II Diabetes
1.5Pertusus
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis


 Download the PDF from VitaminDWiki


Image Image


Marissa Penna-Martinez and Klaus Badenhoop
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine 1, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
(This article belongs to the Special Issue Genetics and Functional Genomics of Diabetes Mellitus)

The etiology and pathophysiology of type 1 diabetes remain largely elusive with no established concepts for a causal therapy. Efforts to clarify genetic susceptibility and screening for environmental factors have identified the vitamin D system as a contributory pathway that is potentially correctable. This review aims at compiling all genetic studies addressing the vitamin D system in type 1 diabetes. Herein, association studies with case control cohorts are presented as well as family investigations with transmission tests, meta-analyses and intervention trials. Additionally, rare examples of inborn errors of vitamin D metabolism manifesting with type 1 diabetes and their immune status are discussed.
We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation. Associations, however, are tenuous in relation to the ethnic background of the studied populations. Intervention trials identify the specific requirements of adequate vitamin D doses to achieve vitamin D sufficiency. Preliminary evidence suggests that doses may need to be individualized in order to achieve target effects due to pharmacogenomic variation.

Created by admin. Last Modification: Thursday April 20, 2017 15:32:49 UTC by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
7928 T1D VDR T2B.jpg admin 20 Apr, 2017 15:30 142.63 Kb 6
7927 T1D VDR T2A.jpg admin 20 Apr, 2017 15:30 77.61 Kb 6
7926 Genes and T1 Diabetes.pdf PDF 2017 admin 20 Apr, 2017 15:03 504.96 Kb 4
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