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Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016

Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis.

PLoS One. 2016 Feb 19;11(2):e0149576. doi: 10.1371/journal.pone.0149576. eCollection 2016.
Han WG1, Hodemaekers HM2, Nagarajah B2, Poelen MM1, Helm K1, Janssen R2, van Els CA1.

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Pertussis, caused by infection with the gram negative B. pertussis bacterium, is a serious respiratory illness that can last for months. While B. pertussis infection rates are estimated between 1-10% in the general population, notifications of symptomatic pertussis only comprise 0.01-0.1% indicating that most individuals clear B. pertussis infections without developing (severe) clinical symptoms. In this study we investigated whether genetic risk factors are involved in the development of symptomatic pertussis upon B. pertussis infection. Single-nucleotide polymorphisms (SNPs) in candidate genes, MBL2, IL17A, TNFα, VDR, and IL10 were genotyped in a unique Dutch cohort of symptomatic clinically confirmed (ex-)pertussis patients and in a Dutch population cohort. Of the seven investigated SNPs in five genes, a polymorphism in the Vitamin D receptor (VDR) gene (rs10735810) was associated with pertussis. The VDR major allele and its homozygous genotype were more present in the symptomatic pertussis patient cohort compared to the control population cohort. Interestingly, the VDR major allele correlated also with the duration of reported pertussis symptoms. Vitamin D3 (VD3) and VDR are important regulators of immune activation. Altogether, these findings suggest that polymorphisms in the VDR gene may affect immune activation and the clinical outcome of B. pertussis infection.

PMID: 26894582 PMCID: PMC4760950

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  • pertussis = whooping cough
  • A poor Vitamin D Receptor restricts the amount of vitamin D which actually gets to cells (where the benefit happens)
  • There is a greatly increased risk for over 30 diseases associated with poor Vitamin D Receptors

See also VitaminDWiki

Vitamin D Receptor category has the following

189 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 37 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

See also web

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Attached files

ID Name Comment Uploaded Size Downloads
7952 Pertussis Calif.jpg admin 01 May, 2017 11:40 37.46 Kb 38
7321 Severe Pertussis VDR.jpg admin 12 Nov, 2016 15:16 38.63 Kb 81
7320 Severe Pertussis.pdf PDF 2016 admin 12 Nov, 2016 15:16 251.66 Kb 70
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