Vitamin D and subjective memory complaint in community-dwelling older adults.
Curr Alzheimer Res. 2018 Feb 1. doi: 10.2174/1567205015666180201153735. [Epub ahead of print]
Seniors living at home, no dementia
See also VitaminDWiki
- "Senior moment" 25X more likely with low vitamin D - Feb 2012 -also authored by Annweiler
- Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012
- Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT Jan 2017
- Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT April 2017
- Better memory if take lots of vitamin D (senior rats) – May 2015
- Slower cognitive decline if higher vitamin D (1500 adults, 5 years) – Feb 2018
- Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
- Short-term memory 2X better for those who took slightly more vitamin D 14 years before – Sept 2014
- Dementia 13X more likely in elderly with low vitamin D – May 2014
Cognitive category starts with the following
Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 960 items Nov 2017
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017
37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn
C1, Doineau L2, Gerigne L2, Provendier A2, Karras SN3, Beauchet O4, Fantino B5, Duval GT5.
1 Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933 Angers cedex 9. France.
2 School of Medicine, University of Angers, UNAM, Angers. France.
3 Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle U. of Thessaloniki, Thessaloniki. Greece.
4 Dept of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill U., Montreal, Quebec. Canada.
5 Dept. of Neuroscience, Division of Geriatric Medicine; University Memory Clinic; UPRES EA 4638, UNAM, Angers University Hospital, Angers. France.
Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders.
To determine among older community-dwellers whether higher serum 25-hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering the different subtypes of memory complaints.
One hundred eighty Caucasian community-dwellers with memory complaint and no dementia (mean±standard deviation, 71.1±3.4years; 33.3%female) from the French 'EVATEM study' were included in this analysis. Subjective memory complaints regarding memory lapses, problems learning new information, problems finding words, problems calculating and problems concentrating were assessed using a standardized questionnaire. Participants were categorized according to the highest tertile of serum 25OHD (i.e., ≥68nmol/L). Age, gender, body mass index, morbidities burden, use of vitamin D supplements, cognitive performance, mood, serum concentrations of calcium, parathyroid hormone and vitamin B12, creatinine clearance, and season of evaluation were used as potential confounders.
Compared to participants with 25OHD<68nmol/L (n=121), those with 25OHD≥68nmol/L had less often problems learning new information (P=0.027). There were no between-group differences for the other memory complaints. The highest 25OHD tertile was cross-sectionally associated with fewer problems learning new information (odds ratio (OR)=0.48, P=0.029), even after adjustment for potential confounders (OR=0.32, P=0.039).
Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. This novel finding provides a scientific base for vitamin D replacement trials attempting to improve older patients' subjective experience of cognitive decline.
PMID: 29422004 DOI: 10.2174/1567205015666180201153735
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