Low 25-Hydroxyvitamin D Concentrations and Risk of Incident Cognitive Impairment in Black and White Older Adults: The Health ABC Study.
J Nutr Gerontol Geriatr. 2018 Mar 5:1-13. doi: 10.1080/21551197.2017.1419899. [Epub ahead of print]
Kilpatrick L1, Houston DK2, Wilson VK3, Lovato J4, Ayonayon HN5, Cauley JA6, Harris T7, Simonsick EM5, Yaffe K5, Kritchevsky SB2, Sink KM8.
Cognitive category starts with the following
Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
see also Alzheimers-Cognition - Overview
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Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017
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Includes discussion by Dr. Cannell and Dr. David Llewellyn
Overview Dark Skin and Vitamin D contains the following summary
FACT - - People with dark skins have more health problems and higher mortality rate than those with light skins
FACT - - People with dark skins have low levels of vitamin D
FACT - - People with light skins who have low vitamin D have health problems
OBSERVATION - - The health problems of whites with low level of vitamin D are similar to those with dark skins
CONCLUSION - - People with dark skins have more health problems due to low levels of vitamin D
Using data from the Health, Aging, and Body Composition study, we examined whether low 25-hydroxyvitamin D (25OHD) concentrations were associated with prevalent or incident cognitive impairment. Serum 25(OH)D concentrations were measured in 2,786 older adults and categorized as <20 ng/mL, 20 to <30 ng/mL, or ≥30 ng/mL.
Cognitive impairment was defined as a score >1.5 standard deviations below race and education specific means on either digit symbol substitution test or modified mini-mental state test. Logistic regression determined the odds of cognitive impairment at baseline and year 5 by 25(OH)D category.
25(OH)D concentrations were <30 ng/mL in 57.3% of whites and 84.6% of blacks. After excluding participants with baseline cognitive impairment (n = 340),
- 13% of whites and 13% of blacks developed cognitive impairment by year 5.
In whites, 25(OH)D concentrations <30 ng/mL were not associated with prevalent or incident cognitive impairment. Black participants with 25(OH)D concentrations <20 ng/mL had a higher odds of prevalent, but not incident cognitive impairment (OR (95% CI): 2.05 (1.08-3.91), p = 0.03) compared to participants with 25(OH)D concentrations ≥30 ng/mL. Low 25(OH)D concentrations were associated with twofold higher odds of prevalent cognitive impairment in blacks.
PMID: 29505349 DOI: 10.1080/21551197.2017.1419899
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