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Role of Vitamin D in the Pathogenesis of Diabetes – Holick July 2017

Principles of Diabetes Mellitus, pp 107-119, 08 July 2017
Nadine E. Palermo , Michael F. Holick

See also VitaminDWiki

Search VitaminDWiki for HOLICK DIABETES 1860 items as of July 2017

Overview Diabetes and vitamin D contains this summary]

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 333 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Pages listed in BOTH of the categories Diabetes and Intervention


Pages listed in BOTH of the categories Diabetes and Meta-analysis


With the predicted continued rise in patients diagnosed with diabetes and anticipated progressive loss of beta cell function in those already affected, there has been ongoing interest in understanding the mechanism of pathogenesis as well as identifying factors that may modulate dysglycemia.
Several observational and interventional studies have sought to demonstrate improvement in glycemic control and insulin sensitivity based on vitamin D status.
While this relationship has not been consistently seen in medical literature, is it likely due to the

  • duration of intervention,
  • dose and underlying vitamin D status

as the most pronounced effect of vitamin D supplementation on glycemic control has been observed in patients with vitamin D deficiency/insufficiency and who do not have established diabetes.

Evidence suggests that vitamin D’s effect on the immune system may play a role in reducing risk for developing type 1 diabetes. Therefore, improvement in vitamin D status throughout life may help reduce risk for developing both type 1 and type 2 diabetes as well as improve glycemic control in those who have these disorders.

References

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