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Rate of vitamin D supplementation by Blacks increases 16X after getting Multiple Sclerosis – Feb 2018

Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis

Nutrients 2018,10,184; doi:10.3390/nu10020184
Annette Langer-Gould h*, Robyn M. Lucas , Anny H. Xiang , Jun Wu 3, Lie H. Chen 3,
Edlin Gonzales 3, Samantha Haraszti 3,4, Jessica B. Smith 3, Hong Quach and Lisa F. Barcellos 5

* Correspondence: annette.m.langer-gould at kp.org; Tel.: +1-(626)-564-3992; Fax: +1-(626)-564-3403


Many MSers increase their vitamin D intake, but rarely as much as is needed to reverse the symptoms

Overview MS and vitamin D starts with the following summary

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

 Download the PDF from VitaminDWiki


Smaller increase in Vitamin D supplementation by Hispanics and Whites,
   but all about 20% if have MS

Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.

Created by admin. Last Modification: Friday February 23, 2018 17:22:44 UTC by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
9396 MS Race.jpg admin 23 Feb, 2018 16:55 86.81 Kb 25
9395 UV MS.pdf PDF 2018 admin 23 Feb, 2018 16:55 443.65 Kb 13
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