Association of VDR polymorphisms ( Taq I and Bsm I) with prostate cancer: a new meta-analysis.
J Int Med Res. 2017 Feb;45(1):3-10. doi: 10.1177/0300060516668939. Epub 2017 Jan 17.
Liu S1, Cai H1, Cheng W1, Zhang H1, Pan Z1, Wang D2.
1 Department of Urology Surgery, Taizhou University Affiliated Taizhou Municipal Hospital, Taizhou, China.
2 Department of Clinical Laboratory Medicine, Taizhou University Affiliated Taizhou Municipal Hospital, Taizhou, China.
Items in both categories Prostate Cancer and Dark Skin are listed here:
- Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017
- Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
- Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
- Higher rate of prostate cancer in AA may decrease if take vitamin D – July 2016
- Prostate Cancer incidence and death 2X more often among black men (vitamin D not mentioned) - July 2015
- Tanning potential predicts risk of Prostate Cancer in Blacks – Nov 2014
- PSA levels in blacks were not changed by 3 months of 4,000 IU of vitamin D (not enough) – June 2014
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 37 health problems click here for details
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:
|1) Vitamin D supplement|
Sun, Ultraviolet -B
| Vitamin D in the blood |
and thus to the cells
|2) Magnesium||Vitamin D in the blood |
AND to the cells
|3) Omega-3||Vitamin D to the cells|
|4) Resveratrol||Vitamin D to the cells|
|5) Intense exercise||Vitamin D Receptor|
|6) Get prescription for VDR activator|
|Vitamin D Receptor|
|7) Quercetin (flavonoid)||Vitamin D Receptor|
If poor Vitamin D Receptor
|9.6||Chronic Periodontitis |
|5.8||Low back pain in athletes|
|5||Coronary Artery Disease|
|4||polycystic ovary syndrome|
|3.1||Lumbar Disc Degeneration|
|3.1||Colon Cancer survival|
|2.6||Lupus in children|
|2||Melanoma Non-melanoma Skin Cancers|
|1.9||Early tooth decay|
|1.6||Diabetes - Type I|
|1.6||Prostate Cancer while black|
|1.5||Diabetes -Type II|
FREE PDF is online
Objective Prostate cancer is a malignant tumour that poses a serious risk to human health. Epidemiological studies suggest that it may be associated with vitamin D receptor gene ( VDR) polymorphisms. Previous work investigated potential risks between Taq I (rs731236) and Bsm I (rs1544410) VDR polymorphisms with prostate cancer in humans; however, results are inconsistent.
Methods We conducted a meta-analysis to retrieve genetic association analyses of rs731236 and rs1544410 polymorphisms with prostate cancer from studies published between 2006-2016. Pooled odds ratios with 95% confidence intervals were used to assess genetic associations, and heterogeneity was assessed by Q and I2 statistics.
Results Our findings suggest a significant association between rs731236 and prostate cancer risk in Asians and African Americans, but rs1544410 was not associated with prostate cancer under three genetic models.
Conclusion Future studies including larger sample sizes and the analysis of gene functions are needed to help develop prostate cancer treatment.
PMID: 28222630 DOI: 10.1177/0300060516668939
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