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Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017

Serum 25-hydroxyvitamin D, vitamin D binding protein, and prostate cancer risk in black men.

Cancer. 2017 Jul 15;123(14):2698-2704. doi: 10.1002/cncr.30634. Epub 2017 Apr 3.
Layne TM1,2, Weinstein SJ2, Graubard BI2, Ma X1,3, Mayne ST1,3, Albanes D2.
1 Chronic Disease Epidemiology Department, Yale School of Public Health, New Haven, Connecticut.
2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
3 Yale Comprehensive Cancer Center, Yale University, New Haven, Connecticut.

BACKGROUND:
Few studies have prospectively examined the relationship between vitamin D status and prostate cancer risk in black men, a group at high risk for both low vitamin D status and prostate cancer.

METHODS:
Among black men in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we identified 226 prostate cancer cases and 452 controls matched on age at randomization (±5 years), date of blood draw (±30 days), calendar year of cohort entry, and time since baseline prostate cancer screening (±1 year). Conditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between serum 25-hydroxyvitamin D [25(OH)D], vitamin D binding protein (DBP), the 25(OH)D:DBP molar ratio, and prostate cancer risk.

RESULTS:
Serum 25(OH)D was not associated with overall prostate cancer (Q4 vs Q1: OR, 0.73; 95% CI, 0.40-1.33; P for trend = .25), although there were apparent inverse associations for nonaggressive disease (global P = .03, clinical stage I/II, and Gleason score <7) and among men ≥62 years old (P for interaction = .04) that were restricted to Q3.

Interestingly, serum DBP was significantly inversely associated with prostate cancer risk (Q4 vs Q1: OR, 0.45; 95% CI, 0.20-1.00; P for trend = .03), whereas the 25(OH)D:DBP molar ratio was not. Results were similar when we mutually adjusted for 25(OH)D and DBP, and we found no evidence of interaction between the two.

CONCLUSION:
Our study suggests higher (versus lower) circulating DBP may be independently associated with a decreased prostate cancer risk in black men independent of 25(OH)D status.

PMID: 28369777 PMCID: PMC5498231 [Available on 2018-07-15] DOI: 10.1002/cncr.30634

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