Loading...
 
Register Log In Login with facebook

Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017

Maternal-fetal vitamin D receptor polymorphisms significantly associated with preterm birth.

Arch Gynecol Obstet. 2017 Jun 13. doi: 10.1007/s00404-017-4412-y. [Epub ahead of print]

See also VitaminDWiki

It may be more important to test Vit. D Receptor than to test Vit. D blood level

Items in both categories Pregnancy and VDR are listed here:

Vitamin D Receptor category has the following

148 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 30+ health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

See also VitaminDWiki


Rosenfeld T1,2, Salem H1, Altarescu G2, Grisaru-Granovsky S2, Tevet A2, Birk R3.
1 Department of Nutrition, School of Health Sciences, Ariel University, Ariel, Israel.
2 Genetics Unit and Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel.
3 Department of Nutrition, School of Health Sciences, Ariel University, Ariel, Israel. ruthb at ariel.ac.il.

PURPOSE:
Preterm birth (PTB) is a complex trait with strong genetic background, whose etiology is not fully understood. It was recently suggested that pregnancy duration is affected by fetal genetic variation even more than by the maternal genome. Vitamin D receptor (VDR) is involved in embryonic implantation and fertility. We studied the association between both maternal and neonatal vitamin D receptor (VDR) genetic variation and PTB.

METHODS:
Maternal and fetal (umbilical cord) DNA was isolated from Jewish Israeli idiopathic preterm newborns (24-36 weeks, n = 146) and control term newborns (>37 weeks, n = 229). Maternal and fetal VDR polymorphisms (FokI, ApaI, BsmI, TaqI) were analyzed by restriction fragment length polymorphism analysis. Using SPSS analysis to correlate VDR genotypes with phenotypic variation: pregnancy duration, preterm birth and spontaneous miscarriages, adjusted for gravidity, parity and gender of newborn.

RESULTS:
Women homozygous to VDR ApaI (AA) genotype had significant twofold increase risk for PTB [OR 1.973, (CI) 1.183-3.289, p = 0.009] compared to heterozygous women. Male newborns had significant (p < 0.05) 1.73-fold increase of PTB. Women with history of previous (≥1) spontaneous miscarriage had a significant increased risk for PTB if their newborn carried either of the VDR BsmI homozygous (BB or bb) genotypes compared to the heterozygous (Bb) genotype [OR 6.857, (CI) 1.273-36.934, p = 0.018 and OR 9.231, (CI) 1.753-48.618, p = 0.008, respectively], or VDR ApaI homozygous (AA or aa) genotype compared to heterozygous (Aa) genotype [OR 4.33, (CI) 1.029-18.257, p = 0.046 and OR 7.2, (CI) 1.34-38.917, p = 0.021, respectively].

CONCLUSIONS:
We show association between maternal and fetal VDR genotype variants with PTB.

PMID: 28612095 DOI: 10.1007/s00404-017-4412-y
Publisher wants $40 for the PDF

Created by admin. Last Modification: Thursday June 15, 2017 17:00:45 UTC by admin. (Version 5)
See any problem with this page? Report it to the webmaster.