Maternal-fetal vitamin D receptor polymorphisms significantly associated with preterm birth.
Arch Gynecol Obstet. 2017 Jun 13. doi: 10.1007/s00404-017-4412-y. [Epub ahead of print]
It may be more important to test Vit. D Receptor than to test Vit. D blood level
Items in both categories Pregnancy and VDR are listed here:
- Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017
- Preterm birth and Vitamin D Receptor – Dec 2016
- Preterm birth 3.3 times more likely if Vitamin D Receptor gene problem – Aug 2016
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone affects the T cell vitamin D receptor (2 abstracts) – March 2015
- Progesterone enhances Vitamin D ability to regulate T cells and immunity – Dec 2014
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 30+ health problems click here for details
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:
|1) Vitamin D supplement|
Sun, Ultraviolet -B
| Vitamin D in the blood |
and thus to the cells
|2) Magnesium||Vitamin D in the blood |
AND to the cells
|3) Omega-3||Vitamin D to the cells|
|4) Resveratrol||Vitamin D to the cells|
|5) Intense exercise||Vitamin D Receptor|
|6) Get prescription for VDR activator|
|Vitamin D Receptor|
|7) Quercetin (flavonoid)||Vitamin D Receptor|
See also VitaminDWiki
- Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015
- Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017 >10,000 miscarriages
- Search VitaminDWiki for MISCARRIAGE 302 pages as of June 2017
Rosenfeld T1,2, Salem H1, Altarescu G2, Grisaru-Granovsky S2, Tevet A2, Birk R3.
1 Department of Nutrition, School of Health Sciences, Ariel University, Ariel, Israel.
2 Genetics Unit and Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel.
3 Department of Nutrition, School of Health Sciences, Ariel University, Ariel, Israel. ruthb at ariel.ac.il.
Preterm birth (PTB) is a complex trait with strong genetic background, whose etiology is not fully understood. It was recently suggested that pregnancy duration is affected by fetal genetic variation even more than by the maternal genome. Vitamin D receptor (VDR) is involved in embryonic implantation and fertility. We studied the association between both maternal and neonatal vitamin D receptor (VDR) genetic variation and PTB.
Maternal and fetal (umbilical cord) DNA was isolated from Jewish Israeli idiopathic preterm newborns (24-36 weeks, n = 146) and control term newborns (>37 weeks, n = 229). Maternal and fetal VDR polymorphisms (FokI, ApaI, BsmI, TaqI) were analyzed by restriction fragment length polymorphism analysis. Using SPSS analysis to correlate VDR genotypes with phenotypic variation: pregnancy duration, preterm birth and spontaneous miscarriages, adjusted for gravidity, parity and gender of newborn.
Women homozygous to VDR ApaI (AA) genotype had significant twofold increase risk for PTB [OR 1.973, (CI) 1.183-3.289, p = 0.009] compared to heterozygous women. Male newborns had significant (p < 0.05) 1.73-fold increase of PTB. Women with history of previous (≥1) spontaneous miscarriage had a significant increased risk for PTB if their newborn carried either of the VDR BsmI homozygous (BB or bb) genotypes compared to the heterozygous (Bb) genotype [OR 6.857, (CI) 1.273-36.934, p = 0.018 and OR 9.231, (CI) 1.753-48.618, p = 0.008, respectively], or VDR ApaI homozygous (AA or aa) genotype compared to heterozygous (Aa) genotype [OR 4.33, (CI) 1.029-18.257, p = 0.046 and OR 7.2, (CI) 1.34-38.917, p = 0.021, respectively].
We show association between maternal and fetal VDR genotype variants with PTB.
PMID: 28612095 DOI: 10.1007/s00404-017-4412-y
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