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Pregnancy and Vitamin D – meta-analysis April 2015

ENDOCRINOLOGY IN PREGNANCY: Influence of maternal vitamin D status on obstetric outcomes and the foetal skeleton

 
Eur J Endocrinol April 10, 2015 EJE-14-0826
Rebecca Moon, Nicholas Harvey and Cyrus Cooper cc at mrc.soton.ac.uk
R Moon, MRC Lifecourse Epidemiology Unit, University of Southampton, SOUTHAMPTON, United Kingdom
N Harvey, MRC Lifecourse Epidemiology Unit, University of Southampton, SOUTHAMPTON, United Kingdom
C Cooper, MRC Lifecourse Epidemiology Unit, University of Southampton, SOUTHAMPTON, United Kingdom

See also VitaminDWiki
Pregnancy category listing has 884 items along with related searches

Overview Pregnancy and vitamin D has the following summary

IU Cumulative Benefit Blood level CofactorsCalcium $*/month
200 Better bones for mom
with 600 mg of Calcium
6 ng/ml increase Not needed No effect $0.10
400 Less Rickets (but not zero with 400 IU)
3X less adolescent Schizophrenia
Fewer child seizures
20-30 ng/ml Not needed No effect $0.20
2000 2X More likely to get pregnant naturally/IVF
2X Fewer dental problems with pregnancy
8X less diabetes
4X fewer C-sections (>37 ng)
4X less preeclampsia (40 ng vs 10 ng)
5X less child asthma
2X fewer language problems age 5
42 ng/ml Desirable < 750 mg $1
4000 2X fewer pregnancy complications
2X fewer pre-term births
49 ng/ml Should have
cofactors
< 750 mg $3
6000 Probable: larger benefits for above items
Just enough D for breastfed infant
More maternal and infant weight
Should have
cofactors
< 750 mg $4

The articles in Pregnancy AND Meta-analysis are here:


Vitamin D status is increasingly associated with wide ranging clinical outcomes. There is now a wealth of observational studies reporting on its associations with obstetric complications, including preeclampsia, gestational diabetes and mode and timing of delivery. The findings are inconsistent and currently there is a lack of data from high quality intervention studies to confirm a causal role for vitamin D in these outcomes. This is similarly true with regards to fetal development, including measures of fetal size and skeletal mineralisation.

Overall, there is an indication of possible benefits of vitamin D supplementation during pregnancy for

  • offspring birthweight,
  • calcium concentrations and bone mass, and for
  • reduced maternal pre-eclampsia.

However, for none of these outcomes is the current evidence base conclusive, and the available data justify the instatement of high-quality randomised placebo controlled trials in a range of populations and health care settings to establish potential efficacy and safety of vitamin D supplementation to improve particular outcomes.

Received 1 October 2014, Accepted Preprint first posted online on 10 April 2015
 Download the PDF from VitaminDWiki

Figure 1: Forest plot of the association between maternal vitamin D status and risk of preeclampsia (observational studies)

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Figure 2: Meta-analysis of maternal serum 25(OH)D in pregnancy and gestational diabetes.

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Table 1: Meta-analyses of maternal vitamin D status (intake and serum 25-hydroxyvitamin D level) and risk of pre-eclampsia

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Table 2: Intervention studies of vitamin D supplementation (alone, and in combination with calcium supplementation) in pregnancy to reduce obstetric complications

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Table 3

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5277 Pregnancy GDM.jpg admin 11 Apr, 2015 70.14 Kb 2012
5276 Preg F1 preeclampsia.jpg admin 11 Apr, 2015 52.64 Kb 2352
5275 Preg T3b.jpg admin 11 Apr, 2015 106.84 Kb 1836
5274 Preg T3.jpg admin 11 Apr, 2015 167.08 Kb 1504
5273 Preg T2.jpg admin 11 Apr, 2015 124.97 Kb 688
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5271 Pregnancy April 2015.pdf admin 11 Apr, 2015 2.23 Mb 1062