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Preclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016

Early pregnancy vitamin D status and risk of preeclampsia

The Journal of Clinical Investigation, First published November 14, 2016
Hooman Mirzakhani,1 Augusto A. Litonjua,1,2 Thomas F. McElrath,3 George O’Connor,4 Aviva Lee-Parritz,5 Ronald Iverson,5 George Macones,6 Robert C. Strunk,7 Leonard B. Bacharier,7 Robert Zeiger,8 Bruce W. Hollis,9 Diane E. Handy,10 Amitabh Sharma,1 Nancy Laranjo,1 Vincent Carey,1 Weilliang Qiu,1 Marc Santolini,1,11 Shikang Liu,12 Divya Chhabra,13 Daniel A. Enquobahrie,14 Michelle A. Williams,15 Joseph Loscalzo,16 and Scott T. Weiss1,17

VitaminDWiki

As with many health problems, the more vitamin D the better
50 ng better than 40 ng, which was better than 30 ng, which was better than 20 ng
Note: 4,400 IU daily will only occasionaly result in > 40 ng
Study found a 3.6 times reduction in Preeclampsia if > 30 ng
To get to 40 or 50 ng ( and much more reduction) you need
- much more vitamin D (especially if obese )
- the right type of Vitamin D for your body - example - gut friendly
- Cofactors (which can increase response by 2X)
-Reasons for low response by vitamin D level in the blood
See also VitaminDWiki
Pages listed in BOTH the categories Pregnancy and Hypertension (preeclampsia)

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesProof
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT*
3. Gestational Diabetes 3 times RCT*
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT*
6. C-section - unplanned 1.6 timesObserve
7. Depression AFTER pregnancy 1.4 times RCT*
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT*
10. Childhood Wheezing 1.3 times RCT*
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT*
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT*
16. Childhood Respiratory Tract visits 2.5 times RCT*

Note: Vitamin D reduced preeclampsia risk in both current AND future mother


 Download the PDF from VitaminDWiki
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BACKGROUND. Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia.

METHODS. We assessed the effect of vitamin D supplementation (4,400 vs. 400 IU/day), initiated early in pregnancy (10–18 weeks), on the development of preeclampsia. The effects of serum vitamin D (25-hydroxyvitamin D [25OHD]) levels on preeclampsia incidence at trial entry and in the third trimester (32–38 weeks) were studied. We also conducted a nested case-control study of 157 women to investigate peripheral blood vitamin D–associated gene expression profiles at 10 to 18 weeks in 47 participants who developed preeclampsia.

RESULTS. Of 881 women randomized, outcome data were available for 816, with 67 (8.2%) developing preeclampsia. There was no significant difference between treatment (N = 408) or control (N = 408) groups in the incidence of preeclampsia (8.08% vs. 8.33%, respectively; relative risk: 0.97; 95% CI, 0.61–1.53). However, in a cohort analysis and after adjustment for confounders, a significant effect of sufficient vitamin D status (25OHD =30 ng/ml) was observed in both early and late pregnancy compared with insufficient levels (25OHD <30 ng/ml) (adjusted odds ratio, 0.28; 95% CI, 0.10–0.96). Differential expression of 348 vitamin D–associated genes (158 upregulated) was found in peripheral blood of women who developed preeclampsia (FDR <0.05 in the Vitamin D Antenatal Asthma Reduction Trial [VDAART]; P < 0.05 in a replication cohort). Functional enrichment and network analyses of this vitamin D–associated gene set suggests several highly functional modules related to systematic inflammatory and immune responses, including some nodes with a high degree of connectivity.

CONCLUSIONS. Vitamin D supplementation initiated in weeks 10–18 of pregnancy did not reduce preeclampsia incidence in the intention-to-treat paradigm. However, vitamin D levels of 30 ng/ml or higher at trial entry and in late pregnancy were associated with a lower risk of preeclampsia. Differentially expressed vitamin D–associated transcriptomes implicated the emergence of an early pregnancy, distinctive immune response in women who went on to develop preeclampsia.

TRIAL REGISTRATION. ClinicalTrials.gov NCT00920621.

FUNDING. Quebec Breast Cancer Foundation and Genome Canada Innovation Network. This trial was funded by the National Heart, Lung, and Blood Institute.

Genes and Vitamin D

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Exluded those who did not have asthma in the family

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Attached files

ID Name Comment Uploaded Size Downloads
7429 Excluded.jpg admin 02 Dec, 2016 11:06 38.07 Kb 212
7428 PE gemes.jpg admin 02 Dec, 2016 11:05 57.08 Kb 228
7427 Preeclampsia vs Vit D.jpg admin 02 Dec, 2016 11:05 25.76 Kb 187
7426 Less Preclampsia if more than 30 ng.pdf PDF 2016 admin 02 Dec, 2016 11:04 1.92 Mb 148
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