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Patent application for a skin cream which enhances production of vitamin D – Holick July 2013

Compositions for Providing Vitamin D Year Round and Uses Thereof


Methods for enhancing the ability of an individual, exposed to sunlight, to produce vitamin D via the skin. Pharmaceutical compositions comprising provitamin D and at least one of lumisterol and tachysterol and analogs and derivatives thereof are also disclosed.

Claim 1
A composition comprising a pharmaceutically acceptable carrier and an effective amount of (a) provitamin D or a derivative or analog thereof; (b) at least one of lumisterol and tachysterol or analogs and/or esters thereof, and (c) a pharmaceutically effective carrier, wherein (a) and (b) are present in amounts effective to provide vitamin D or derivatives or analogs and/or esters thereof to an individual at a particular latitude and/or time of the year.

Description
FIELD OF THE INVENTION
[0001] The invention is in the field of cosmetics and medicinal chemistry. In particular, the present invention relates to topical compositions which provide vitamin D and derivatives thereof throughout the year. The topical compositions of the invention allow a user in the high northern and southern latitudes to produce previtamin D on their skin even when exposed to low energy sunlight in the winter as well as in the morning and evening throughout the year. The compositions comprise provitamin D and at least one of tachysterol and lumisterol, and derivatives and analogs thereof, which photoisomerize to previtamin D, and analogs and derivatives thereof.

SUMMARY OF THE INVENTION
[0015] The present invention is related to the discovery that topical formulations comprising provitamin D and derivatives and analogs thereof together with at least one of lumisterol and tachysterol and derivatives and analogs thereof are effective means of providing vitamin D to individuals throughout the year. The present invention utilizes the low energy UV photoconversion of lumisterol and tachysterol and derivatives and analogs thereof to previtamin D and derivatives and analogs thereof during the winter months and high energy UV photoconversion of provitamin D and derivatives and analogs thereof to previtamin D and derivatives and analogs thereof in the summer months as a method of producing vitamin D and derivatives and analogs thereof in the skin throughout the year.


Comment by VitaminDWiki

If this works, it will be a real breakthru for getting vitamin D:

  1. off season,
  2. other than middle of the day (too hot),
  3. by seniors
  4. perhaps those with dark skins

See also VitaminDWiki

See also web

  • tachysterol Definition and how to pronounce the word
    An isomer of ergosterol that forms vitamin D2 when irradiated with ultraviolet light.
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