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PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018

High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea and premenstrual syndrome in adolescents

Bahrami, A, Avan, A, Sadeghnia, HR, Esmaeili, H, Tayefi, M, Ghasemi, F, Salehkhani, FN, Arabpour-Dahoue, M, Rastegar, A, Ferns, G, Bahrami-Taghanaki, H and Ghayour-Mobarhan, M Gynecological Endocrinology. ISSN 1473-0766 (Accepted)

Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received 9 high-dose vitamin D supplements (as 50000 IU/ week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in 4 categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects.

The prevalence of PMS after the intervention fell from 14.9% to 4.8% (P<0.001).
Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well decrement in pain severity of dysmenorrhea (P<0.05). High dose vitamin D supplementation can reduced the prevalence of PMS and dysmenorrhea as well has positive effects on the physical and psychological symptoms of PMS.

URI: http://sro.sussex.ac.uk/id/eprint/72540

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