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Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013

Vitamin D receptor (VDR) gene polymorphism influences the risk of osteoporosis in postmenopausal women of Northwest India.

Arch Osteoporos. 2013 Dec;8(1-2):147. doi: 10.1007/s11657-013-0147-y. Epub 2013 Aug 22.
Singh M, Singh P, Singh S, Juneja PK, Kaur T.
Molecular Genetics Laboratory, Department of Human Genetics, Punjabi University, Patiala, Punjab, India.

Abstract: The influence of VDR gene for the risk of osteoporosis has remained inconclusive.
VDR gene polymorphism in relation to BMD in postmenopausal women of Northwest India revealed a susceptibility haplotype AGT.
Possession of this haplotype exacerbates the risk of osteoporosis by 2.8 times, which manifests in recessive mode of inheritance.

PURPOSE:The purpose of this study is to understand the influence of coordinated effect of various single nucleotide polymorphisms (SNPs) within vitamin D receptor (VDR) gene for the risk of osteoporosis, which has remained undefined so far.

METHODS: Four pertinent SNPs of VDR gene, i.e., rs2228570, rs1544410, rs17879735, and rs731236 were examined with polymerase chain reaction-restriction fragment length polymorphism in dual energy X-ray absorptiometry verified 188 osteoporotics, 115 osteopenics, and 147 normal postmenopausal women of Northwest India.

RESULTS:Minor allele 'T' of rs2228570 showed significant influence for the risk of osteoporosis (OR 1.60, 95%CI 1.16-2.20, P = 0.004) and also in dominant (OR 2.32, 95%CI 1.47-3.64, P = 0.0006) and additive model (OR 2.41, 95%CI 1.49-3.87, P = 0.0006) after Bonferroni correction. Minor allele (T) of rs2228570 showed an allele dose effect with BMD of L1-L4 (P = 0.009) and FN (P = 0.036).
Disease association analysis exposed a susceptibility haplotype AGT which influences the risk of

  • osteopenia (OR 2.04, 95%CI 1.03-4.08, P = 0.036) and
  • osteoporosis (OR 2.90, 95%CI 1.61-5.38, P = 0.00005)

after adjusting the effects of age, BMI and years since menopause.
This haplotype is significantly associated with BMDs at lumbar spine (P = 0.0001) and femoral neck (P = 0.016).

CONCLUSION: In-depth analysis of this haplotype with other methods of Wald statistics and Akaike information criterion confirmed that carriers of each unit of this haplotype AGT increases the risk of osteoporosis by a factor of 2.80 ± 0.34 (β ± SE) which manifests (P = 0.1 × 10(-6)) in its recessive mode of inheritance.

PMID: 23975234


What to do about it?

With most vitamin D gene problems the simple remedy is to take more vitamin D so as to raise the vitamin D in the cell necessary to prevent/treat a disease. Sometimes this is raising the blood level, but not always.
Before gene typing it was noticed that some people did not get as much benefit from vitamin D as others. Genes are providing some insight as to why.

See also VitaminDWiki

Vitamin D Receptor category has the following

186 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 37 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

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