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Only a select group of women will get a modest benefit from 800 IU of vitamin D – Jan 2017

Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial.

Nutrients. 2017 Jan 4;9(1). pii: E30. doi: 10.3390/nu9010030.

VitaminDWiki Summary
  • Non-pregnant women, 58% were on contraceptives, German winter
  • . . .” users of hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D levels . . .”
  • “ . . age ≥18 to ≤45 years, body mass index (BMI) 17 to 30 kg/m2, good physical and mental health. . . “
  • Note: Women need more than 800 IU if start at a lower level of vitamin D
    • obese
    • pregnant or recently pregnant
    • not on contraceptives
    • dark skin
    • taking a variety of drugs
    • in poor health (>100 diseases are associated with low vitamin D)
    • elderly (gut, liver, and kidney do not process vitamin D as efficiently)

See also VitaminDWiki

Raising Vitamin D level to 20 nanograms rarely results in any benefits
40 nanograms has been proven many time to provide benefits

The pills contained much more than Vitamin D

Perhaps the added vitamind increased the response
Image

Women on contraceptives started with higher level and had bigger responses

Image

 Download the PDF from VitaminDWiki

Pilz S1, Hahn A2, Schön C3, Wilhelm M4, Obeid R5.

  • 1 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. stefan.pilz at chello.at.
  • 2 Institute of Food Science and Human Nutrition, Leibniz University of Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany. hahn at nutrition.uni-hannover.de.
  • 3 BioTeSys GmbH, Schelztorstrasse 54-56, 73728 Esslingen, Germany. c.schoen at biotesys.de.
  • 4 Department of Mathematics, Natural and Economic Sciences, University of Applied Science Ulm, Albert-Einstein-Allee 55, 89081 Ulm, Germany. wilhelm at hs-ulm.de.
  • 5 Aarhus Institute of Advanced Studies, University of Aarhus, Hoegh-Guldbergs Gade 6B, Building 1632, DK-8000 Aarhus, Denmark. rima.obeid at uks.eu.

The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25(OH)D. 196 participants completed the trial. Increases in 25(OH)D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25(OH)D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient.

PMID: 28054964 PMCID: PMC5295074 DOI: 10.3390/nu9010030

Created by admin. Last Modification: Saturday June 17, 2017 15:27:13 UTC by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
8112 800 IU contraceptive.jpg admin 17 Jun, 2017 15:01 66.03 Kb 38
8111 800 IU plus.jpg admin 17 Jun, 2017 15:00 65.26 Kb 49
8110 800 IU women 20 ng.pdf PDF 2017 admin 17 Jun, 2017 15:00 1.83 Mb 22
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