Loading...
 
Register Log In Login with facebook

Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018

Gene. 2017 Oct 12. pii: S0378-1119(17)30854-5. doi: 10.1016/j.gene.2017.10.029. [Epub ahead of print]
María CR1, Antonio CJ2, Jacqueline SR3, Emilio GJ3, Sofia V4, Javier M4, Blanca RM3.
1 Faculty of Health Sciences, University of Granada (Spain), Av. Ilustración 60, 18016 Granada, Spain. macoro at ugr.es.
2 Andalusian Public Health System Biobank, Av. del Conocimiento s/n, 18016, Granada, Spain.
3 Faculty of Health Sciences, University of Granada (Spain), Av. Ilustración 60, 18016 Granada, Spain.
4 Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, 18100, Spain.


Image
Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR). The aim of this study was to investigate the contribution of the VDR gene to obesity-related phenotypes in a population of Caucasian young adults. The study population consisted of 701 healthy Spanish young adults (mean age 20.41±2.48). Three single-nucleotide polymorphisms (SNPs) of VDR (TaqI, BsmI and FokI) were selected as genetic markers. Body composition measurements including weight, body mass index (BMI), fat mass (FM), percentage of fat mass (PFM, fat-free mass (FFM) and visceral fat level (VFL) were analysed. Differences in obesity traits across the genotypes were determined using analysis of covariance (ANCOVA). The FokI polymorphism showed a significant association with PFM across the whole population after adjusting for age and sex (p=0.022). Age-adjusted analysis revealed an association between body weight and the TaqI and BsmI SNPs in males (p=0.033 and p=0.028, respectively). However, these positive findings did not remain significant after applying the Bonferroni correction for multiple testing. Our findings suggest that VDR genetic variants are unlikely to play a major role in obesity-related phenotypes in a population of Caucasian young adults.

PMID: 29032145 DOI: 10.1016/j.gene.2017.10.029


Note Bonferroni correction for multiple testing probably did not have enough gene data, see GWS Forum below
http://gwasforum.blogspot.com/p/multiple-testing.html

Paid Publisher $36 for the PDF

Created by admin. Last Modification: Monday November 13, 2017 02:22:47 UTC by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
8725 Obesity VDR.jpg admin 13 Nov, 2017 02:10 67.39 Kb 22
See any problem with this page? Report it to the webmaster.