Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.
BMC Med Genet. 2017 Aug 22;18(1):90. doi: 10.1186/s12881-017-0454-z.
Bienertová-Vašků J1,2, Zlámal F3, Pohořalá A3, Mikeš O3, Goldbergová-Pávková M4, Novák J4, Šplíchal Z4, Pikhart H3,5.
Many diseases are strongly associated with Vitamin D Receptor
Items in both categories Obesity and Vitamin D Receptor are listed here:
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D Receptor and Obesity – several studies
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.
A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.
In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (β = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (β = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (β = -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (β = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (β = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.
Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
PMID: 28830368 PMCID: PMC5568207 DOI: 10.1186/s12881-017-0454-z