Loading...
 
Register Log In Login with facebook

Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017

Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.

BMC Med Genet. 2017 Aug 22;18(1):90. doi: 10.1186/s12881-017-0454-z.
Bienertová-Vašků J1,2, Zlámal F3, Pohořalá A3, Mikeš O3, Goldbergová-Pávková M4, Novák J4, Šplíchal Z4, Pikhart H3,5.

Image

VitaminDWiki Summary

Items in both categories OBESITY and VITAMIN D RECEPTOR:

Vitamin D Receptor category has the following

170 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 35 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
13Sepsis
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1Lumbar Disc Degeneration
3.1Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis if COPD
2.7Gastric Cancer
2.6Lupus in children
2.4Lung Cancer
2.3Autism
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma
2Myopia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis


 Download the PDF from VitaminDWiki

BACKGROUND:
There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.

METHODS:
A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.

RESULTS:
In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (β = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (β = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (β = -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (β = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (β = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.

CONCLUSION:
Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.

PMID: 28830368 PMCID: PMC5568207 DOI: 10.1186/s12881-017-0454-z

Created by admin. Last Modification: Thursday September 7, 2017 10:46:34 UTC by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
8399 Obesity VDR.jpg admin 07 Sep, 2017 10:38 73.73 Kb 16
8398 Obesity VDR.pdf PDF 2017 admin 07 Sep, 2017 10:37 526.79 Kb 7
See any problem with this page? Report it to the webmaster.