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Need 460 IU of vitamin D to get half of young Japanese women to even 20 ng level – Nov 2017

Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women.

J Bone Miner Metab. 2017 Nov 9. doi: 10.1007/s00774-017-0879-7. [Epub ahead of print]

Ohta H1, Kuroda T2, Tsugawa N3, Onoe Y4, Okano T5, Shiraki M6.
1 Clinical Medical Research Center, International University of Health and Welfare, Women's Medical Center, Sanno Medical Center, 8-5-35 Akasaka, Minato-ku, Tokyo, 107-0052, Japan. ohtah at iuhw.ac.jp.
2 Public Health Research Foundation, 1-1-7 Nishiwaseda, Shinjuku-ku, Tokyo, 169-0051, Japan.
3 Laboratory of Public Health, Department of Health and Nutrition, Osaka Shoin Women's University, 4-2-26 Hishiyanishi, Higashi-Osaka, Osaka, 577-8550, Japan.
4 Department of Obstetrics and Gynecology, Tokyo Women's Medical University Hospital, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
5 Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
6 Department of Internal Medicine, Research Institute and Practice for Involutional Diseases, 1610-1 Meisei, Misato, Azumino, Nagano, 399-8101, Japan.

Populations of East Asian countries have been known to have low calcium intakes and low serum 25(OH)D concentrations, suggesting that Ca and vitamin D (VitD)-deficiencies are commonly observed. These nutritional imbalances may lead to low peak bone mass (PBM). The low PBM seen in Ca/VitD-deficient individuals may lead to osteoporosis, as well as an increased risk of fracture. A survey was conducted in young Japanese women (n = 296, 21.2 ± 2.3 years old) on their Ca/VitD intakes and serum 25(OH)D levels, which demonstrated a significant positive correlation between VitD intake and serum 25(OH)D levels (R 2 = 0.020, P = 0.016), and the proportion with serum 25(OH)D over 20 ng/mL was significantly increased with VitD intake (P = 0.013). Serum 25(OH)D was negatively correlated to serum intact parathyroid hormone (R 2 = 0.053, P < 0.001). On receiver operating characteristic curve analysis, the VitD intake threshold for maintaining 25(OH)D levels at 20 ng/mL or higher was 11.6 μg/day or greater. It was suggested that the recommended VitD intake allowance, defined in the Adequate Intakes as 5.5 μg/day, may not be sufficient to maintain serum 25(OH)D levels for bone health.

PMID: 29124437 DOI: 10.1007/s00774-017-0879-7
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