Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study.
Neurology. 2017 Jan 3;88(1):44-51. doi: 10.1212/WNL.0000000000003454. Epub 2016 Nov 30.
Nielsen NM1, Munger KL2, Koch-Henriksen N2, Hougaard DM2, Magyari M2, Jørgensen KT2, Lundqvist M2, Simonsen J2, Jess T2, Cohen A2, Stenager E2, Ascherio A2.
Twice as likely if < 8 ng vs > 20 ng
Alternately: 10 ng increase in vitamin D level ==> 30% less likely to get MS
Multiple Sclerosis 1.9X more likely if low vitamin D during pregnancy – March 2016
Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016
Overview MS and vitamin D
As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS.
We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with the same sex and birth date were retrieved from the Biobank (n = 972). Level of 25-hydroxyvitamin D (25OHD) in the DBSS was measured using liquid chromatography tandem mass spectroscopy. The association between different levels of 25(OH)D and risk of MS was evaluated by odds ratios (OR) calculated in conditional logistic regression models.
We observed that lower levels of 25(OH)D in neonates were associated with an increased risk of MS. In the analysis by quintiles, MS risk was highest among individuals in the bottom quintile (<20.7 nmol/L) and lowest among those in the top quintile of 25(OH)D (≥48.9 nmol/L), with an OR for top vs bottom of 0.53 (95% confidence interval CI 0.36-0.78). In the analysis treating 25(OH)D as a continuous variable, a 25 nmol/L increase in neonatal 25(OH)D resulted in a 30% reduced risk of MS (OR 0.70, 95% CI 0.57-0.84).
Low concentrations of neonatal vitamin D are associated with an increased risk of MS. In light of the high prevalence of vitamin D insufficiency among pregnant women, our observation may have importance for public health.
PMID: 27903815 PMCID: PMC5200855 Available on 2018-01-03 DOI: 10.1212/WNL.0000000000003454