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Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B) – Feb 2016

Cystic fibrosis bronchial epithelial cells have impaired ability to activate Vitamin D.

Acta Paediatr. 2016 Feb 10. Doi: 10.1111/apa.13361. [Epub ahead of print]
Pincikova T1,2,3, Svedin E3, Domsgen E3, Flodström-Tullberg M3, Hjelte L1,2.

  • 1 Stockholm CF Center, Karolinska University Hospital Huddinge, Stockholm, Sweden.
  • 2 Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • 3 Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

The vitamin D receptor system is widely expressed in the human body, including immune system cells and epithelial cells (1). The enzyme responsible for the second hydroxylation step in the production of active vitamin D, 1alpha-hydroxylase (Cyp27B), is not just expressed in the kidneys, as previously thought (2).
Primary lung epithelial cells have been shown to activate vitamin D (3). The focus of recent vitamin D research has been to test the effect of the active form of vitamin D in vitro (4-6) and this has led to increased knowledge about the role of active vitamin D in the immune system and in antimicrobial defence. The picture that has emerged from studies strongly suggests that active vitamin D has an important function in regulating inflammation and infection, including in cystic fibrosis (5-6).

PMID: 26865115 PDF is available in DeepDyve.com

Reference #3

Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form - 2008
 Download the PDF from VitaminDWiki

Respiratory epithelium Wikipedia


See also VitaminDWiki


Cystic Fibrosis category page in VitaminDWiki follows:

(Note: Must click here to see attachements

  • Cystic fibrosis (CF) is a genetic disorder that affects the lungs, pancreas, and other organs, leading to severe respiratory and digestive problems.
  • 162,428 people are living with CF around the world.
  • 105,352 (65%) have been diagnosed
  • 57,076 individuals undiagnosed (Summary by Perplexity AI - March 2024)

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Results

2 pages in both categories: Cystic Fibrosis + Diabetes

3 pages in both categories: Cystic Fibrosis + Top news

2 pages in both categories: Cystic Fibrosis + Hypertension

2 pages in both categories: Cystic Fibrosis + Virus

7 pages in both categories: Cystic Fibrosis + Intervention

3 pages in both categories: Cystic Fibrosis + Intervention - non daily

3 pages in both categories: Cystic Fibrosis + Vitamin D and Magnesium

5 pages in both categories: Cystic Fibrosis + Breathing

3 pages in both categories: Cystic Fibrosis + Genetics

2 pages in both categories: Cystic Fibrosis + Vit D Binding Protein

2 pages in both categories: Cystic Fibrosis + Tuberculosis

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Attached files

ID Name Comment Uploaded Size Downloads
7907 Respiratory Epithelial Cells 2008.pdf admin 10 Apr, 2017 1.49 Mb 763