Serum levels of 25-hydroxyvitamin D predicts infarct volume and mortality in ischemic stroke patients.
J Neuroimmunol. 2017 Dec 15;313:41-45. doi: 10.1016/j.jneuroim.2017.10.002. Epub 2017 Oct 5.
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Low Vitamin D (Q1) predicts far more likely to die
Nie Z1, Ji XC2, Wang J3, Zhang HX4.
- 1 Department of Radiology,The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China. Electronic address: nieyisheng at 163.com.
- 2 EEG Room,The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
- 3 Department of Radiology,The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
- 4 Department of Spinal Surgery,Henan, Luoyang Bone-Setting Hospital, Luoyang, China.
The aim of this study is to determine 25-hydroxyvitamin D [25(OH) D] levels in serum, and investigate their associations with cardiovascular disease (CVD) or all-cause mortality in a 1-year follow-up study in patients with first-ever ischemic stroke.
From November 2013 to October 2015, 387 consecutive patients with ischemic stroke admitted to our hospital were identified. Serum 25(OH) D levels were measured at admission. Infarct volume was measured using diffusion-weighted imaging (DWI). The primary end point was CVD mortality among 1year. The secondary end point was all-cause mortality.
In this study, 387 patients were included. A statistically significant negative correlation between serum 25(OH) D level and infarct volume was found (r=-0.442; P<0.001). There were 74 patients (19.1%, 95%CI: 15.2%-23.0%) died, including 36 CVD mortality (9.3%, 95CI%: 6.4%-12.2%). The mortality distribution across the 25(OH) D quartiles ranged between 39.2% (first quartile) to 5.2% (fourth quartile) for all-cause mortality and between 18.6% (first quartile) to 2.1% (fourth quartile) for CVD mortality. In a multivariate model using the first quartiles of 25(OH) D vs. quartiles 2 through 4 together with the clinical variables, the marker displayed prognostic information CVD mortality: OR for first quartile, 3.06 [95% CI, 2.16-4.95]; all-cause mortality: OR for first quartile, 2.76 [95% CI, 2.01-4.32].
The data show serum levels of 25(OH) D at admission is useful prognostic marker of CVD and all-cause mortality in Chinese patients with ischemic stroke.
PMID: 29153607 DOI: 10.1016/j.jneuroim.2017.10.002
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