Disrupted Bone Metabolism in Long-Term Bedridden Patients.
PLoS One. 2016 Jun 8;11(6):e0156991. doi: 10.1371/journal.pone.0156991. eCollection 2016.
Eimori K1,2, Endo N2, Uchiyama S3, Takahashi Y3, Kawashima H2, Watanabe K2.
36 patients bedridden from birth
Probably not get outdoors, very low levels of vitamin D and poor bones
The poor bone strength is probably due to both inactivity and low vitamin D
This is just an observational stjudy
No attempt to supplement with Vitamin D/UV/sun, nor Magnesium nor Vitamin K - all of which are needed for strong bones
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Bedridden patients are at risk of osteoporosis and fractures, although the long-term bone metabolic processes in these patients are poorly understood. Therefore, we aimed to determine how long-term bed confinement affects bone metabolism.
This study included 36 patients who had been bedridden from birth due to severe immobility. Bone mineral density and bone metabolism markers were compared to the bedridden period in all study patients. Changes in the bone metabolism markers during a follow-up of 12 years were studied in 17 patients aged <30 years at baseline.
The bone mineral density was reduced (0.58±0.19 g/cm3), and the osteocalcin (13.9±12.4 ng/mL) and urine N-terminal telopeptide (NTX) levels (146.9±134.0 mM BCE/mM creatinine) were greater than the cutoff value for predicting fracture. Among the bone metabolism markers studied, osteocalcin and NTX were negatively associated with the bedridden period. During the follow-up, osteocalcin and parathyroid hormone were decreased, and the 25(OH) vitamin D was increased. NTX at baseline was negatively associated with bone mineral density after 12 years.
Unique bone metabolic abnormalities were found in patients who had been bedridden for long periods, and these metabolic abnormalities were altered by further bed confinement. Appropriate treatment based on the unique bone metabolic changes may be important in long-term bedridden patients.
PMID: 27275738 PMCID: PMC4898699 DOI: 10.1371/journal.pone.0156991
Clipped from PDF
“In addition to elderly adults whose daily activity is limited, children and young adults with severe immobility are at a high risk of developing osteoporosis [7–12,19,20]”