The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats
Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi
BMC NeuroscienceBMC series – 201718:81, https://doi.org/10.1186/s12868-017-0400-1© The
This study echos many previous studies with humans - less weight gain and even lose weight with vitamin D
- Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015
- Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Low-calorie diets mimicked by Vitamin D – Dec 2016
- Obesity linked to 13 cancers, the linkage is probably vitamin D – Aug 2016
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Vitamin D stored in fatty tissue may have half life of 12 months (vs 2 months otherwise) – July 2017
Obese with enough Vit D in the Fall may have better Vit D in the Spring than non-obese. Is adding weight a way that the body tries to deal with low Vit D in the winter?
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 116 trials for vitamin D intervention of obesity as of Jan 2016
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Those with darker skins were more likely to be obese Sept 2014
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
Rats gained less weight if take Vitamin D (independant of amount of fat in diet)
Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats.
In the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage. IL-6, IL-1β, NF-Kβ and acetylcholine (ACH) and brain derived neurotropic factor (BDNF) concentrations in hippocampus and hypothalamus homogenate samples were measured by commercial ELISA kits.
Vitamin D administration, reduced food intake and weight gain in studied groups (P < 0.001). Vitamin D reduced hippocampus acetylcholine concentrations in ND + vitamin D group (P < 0.001). High fat diet increased hippocampus IL-6 concentrations significantly (P < 0.05) compared with normal diet receiving groups. Vitamin D could not have significant effects on IL-6 concentrations. Vitamin D administrations reduced IL-1β, NF-Kβ and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group. These reductions were not significant in HFD + vitamin D versus HFD group.
According to our results, vitamin D reduced food intake and weight gain and modulated the HFD induced inflammatory response in hippocampus and hypothalamus of high fat diet induced obesity. Therefore, this neurosteroid, can be suggested as a supplemental therapeutic tool in prevention of obesity related cognitive and neurodegenerative problems.
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