Vitamin D Status in Small Vessel and Large Vessel Ischemic Stroke Patients: A Case-control Study.
Adv Biomed Res. 2017 Nov 30;6:146. doi: 10.4103/2277-9175.219411. eCollection 2017.
Manouchehri N1,2, Vakil-Asadollahi M1, Zandifar A1, Rasmani F3, Saadatnia M2,3.
1 Medical Students' Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
- Low vitamin D at time of stroke predicts 3 X more likely to die in a month (unless add Vit D) – Dec 2017
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Risk of Ischemic Stroke doubles if take more than 1 gram of Calcium daily for years – May 2017
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Overview Stroke and vitamin D
- 3 to 55 X more likely to have these health problems if low Vitamin D
Large vessles are those > 0.1 mm
2/3 of symptomatic strokes are in large vessels
Large vessel strokes have almost 3X the death rate as small vessel strokes
Vitamin D insufficiency is a globally widespread issue. Recent studies have reported a high prevalence of Vitamin D deficiency in Middle-East countries. Studies have shown negative effects of Vitamin D deficiency on endothelium and related diseases such as ischemic brain stroke. Here, we assessed Vitamin D status in patients with different types of ischemic brain stroke and control group.
MATERIALS AND METHODS:
Seventy-five patients (49.3% small vessel, 50.7% large vessel) and 75 controls, matched for age (68.01 ± 10.94 vs. 67.64 ± 10.24) and sex (42 male and 33 female) were recruited. 25(OH) D levels were measured by Chemiluminescence immunoassay. 25(OH) D status was considered as severely, moderately, or mildly deficient and normal with 25(OH) D levels of less than 5, 5-10, 10-16, and >16 ng/ml, respectively.
Mean ± standard error concentration of 25(OH) D in cases and controls were 17.7 ± 1.5 and 26.9 ± 1.6 (P = 0.0001), respectively. Mild, moderate, and severe Vitamin D deficiency were observed in 10.8%, 32.4%, 8.1% vs. 34.3%, 31.5%, 9.5% of small vessel and large vessel group, respectively. 21.7% of the controls were Vitamin D deficient.
Vitamin D deficiency was significantly associated with higher risk for ischemic stroke, (P = 0.000, OR = 7.17, 95% confidence interval: 3.36-15.29).
s25(OH) D levels were significantly higher in control group comparing to small vessel (26.9 ± 1.6 vs. 20.59 ± 2.6 P < 0.05) and large vessel (26.9 ± 1.6 vs. 13.4 ± 1.3 P < 0.001) stroke patients. Small vessel group had significantly higher levels of Vitamin D than large vessel (P < 0.05).
Vitamin D deficiency significantly increases the risk of ischemic stroke, favoring the types with the pathogenesis of large vessel strokes.
PMID: 29285476 PMCID: PMC5735556 DOI: 10.4103/2277-9175.219411