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Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017

VITAMIN D RECEPTOR GENE POLYMORPHISM IN PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS

Biological Markers in Fundamental and Clinical Medicine. - Vol.1, N3. - 2017
DOI: 10.29256/v.01.03.2017.escbm01-14
Myslivets M., Paramonova N., Stepuro T.
Grodno State Medical University, Belarus

VitaminDWiki

Vitamin D Receptor category has the following

195 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 39 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
28Leprosy
13Sepsis
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis

 Download the PDF from VitaminDWiki

Introduction: Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease developing in childhood; its onset occurs before 16 years of age [1]. It is supposed that the heterogeneity of this disease is due to different factors contributed to its pathogenesis. The central role in the pathogenesis of JRA has been attributed to dysregulation of the adaptive immune response, where regulatory T cells, effector T cells and antibody-producing B cells play the leading role. Further, activated B cells produce immunoglobulins, such as rheumatoid factor (RF) and antinuclear antibodies (ANAs). The information about the role of hereditary factors in the pathogenesis of juvenile rheumatoid arthritis has increased with the discovery of the growing number of genetic loci and single polymorphisms associated with RA susceptibility [2]. The most studied susceptibility locus for this disease is the major histocompatibility complex (MHC) located on chromosome 6p. Rheumatoid arthritis is the known risk factor of osteoporosis and bone fragility 3. Vitamin D is one of the key point that interacts with both the immune system and bone tissue. The biological effects of vitamin D are mediated by the functional activity of its receptor. More than 200 single nucleotide polymorphisms were detected in vitamin D receptor (VDR) gene that regulates its activity. VDR polymorphic alleles are the risk factor of such diseases as rheumatoid arthritis, celiac disease, systemic lupus erythematosus and many others. Thus, the study of molecular-genetic markers of JRA is highly required to reveal the hereditary predisposition and early diagnosis of this pathology.

Objectives: The aim of the study was to evaluate the distribution of VDR gene polymorphic alleles BsmI in patients with JRA.

Materials and methods: One hundred and four children were enrolled in this study. The patients were divided into three groups: 37 patients had
JRA according to ILAR classification criteria, 33 children had articular syndrome and 34 hospital controls without any signs of autoimmune or inflammatory diseases. The method of patients genotyping: BsmI (c.IVS7 + 283 G>A) polymorphism of VDR was detected by allele-specific polymerase chain reaction method with the use of reagent kit and in accordance with manufacture’s instruction.

Results: It has been shown that VDR genotype GG was the most frequent among all three groups (18 (48,6%), 18 (54,5%), 20 (58,8%), respectively). In patients with JRA, it was revealed the increased frequency of allele A from 32,4% to 10,2% (p<0,05) as compared to the controls. In patients with articular syndrome frequency of allele A was 28,8%. In our study children with AA genotype had also earlier manifestation of articular syndrome, as compared to the patients with GA VDR gene polymorphism (8.0 (2,3-13,0) years and 13.0 (5,0-13,7) years, respectively (p<0,04).

Conclusions: Thus, minor A allele of polymorphic locus BsmI VDR gene is associated with JRA arising and with predisposition to earlier manifestation of the joint syndrome in patients with JRA.

Prospects for further research. It remains to be further investigated how genetic variants VDR gene may be associated with the activity of the inflammatory process in JRA patients. The finding of our future research will be allowed to answer the question if it is possible to predict complications of JRA and effectiveness of its treatment based on VDR gene polymorphism.

References

  • Ravelli A., Martini A. (2007). Juvenile idiopathic arthritis. Lancet. 369 (9563), 767-778.
  • Suzuki A., Yamamoto K. (2015). From genetics to functional insights into rheumatoid arthritis. Clin Exp Rheumatol. 33 (Suppl. 92), S40-3.
  • Deal C. (2012). Bone loss in rheumatoid arthritis: systemic, periarticular, and focal. Curr Rheumatol Rep. 14, 231-237.
  • Kim K., Jiang X., Cui J. et al. (2015). Interactions between amino acid defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis. Arthritis Rheumatol. 67, 2611-23.
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