Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.
Metab Brain Dis. 2017 Apr;32(2):493-502. doi: 10.1007/s11011-016-9939-2. Epub 2016 Dec 14.
Alfieri DF1, Lehmann MF2, Oliveira SR1, Flauzino T1, Delongui F1, de Araújo MC3, Dichi I4, Delfino VD4, Mezzaroba L5, Simão AN5, Reiche EM6.
- Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Twice as many fatal strokes among whites who were low on vitamin D – Jan 2012
- Stroke or coronary heart disease deaths 30% less likely if had taken more than 440 IU of vitamin D (900,000 patient years) – Jan 2018
- Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017
- Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017
- Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
- Overview Stroke and vitamin D
Modified Rankin Scale (mRS) three-months later
The aim of this study was to investigate whether vitamin D deficiency (VDD) is associated with acute ischemic stroke, inflammatory markers, and short-term outcome. 168 acute ischemic stroke patients and 118 controls were included. The modified Rankin Scale (mRS) was applied up to 8 h of admission (baseline) and after three-months follow-up, and blood samples were obtained up to 24 h of admission to evaluate serum levels of 25-hydroxivitamin D [25(OH)D] and inflammatory markers. Vitamin D levels classified the individuals in sufficient (VDS ≥ 30.0 ng/mL), insufficient (VDI 20.0-29.9 ng/mL), and deficient (VDD < 20.0 ng/mL) status.
Patients had lower levels of 25(OH)D, higher frequency of VDD (43.45% vs. 5.08%, OR: 16.64, 95% CI: 5.66-42.92, p < 0.001), and higher inflammatory markers than controls (p < 0.05).
Patients with VDD showed increased high sensitivity C-reactive protein (hsCRP) levels than those with VDS status (p = 0.043); those with poor outcome presented with lower 25(OH)D levels than those with good outcome (p = 0.008); moreover, 25(OH)D levels were negatively correlated with mRS after three-months follow-up (r = -0.239, p = 0.005). The associations between VDD and higher hsCRP levels and between 25(OH)D levels and poor outcome at short-term in acute ischemic stroke patients suggest the important role of vitamin D in the inflammatory response and pathophysiology of this ischemic event.
PMID: 27975188 DOI: 10.1007/s11011-016-9939-2