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Is too much vitamin D bad – possible causes and cures

It is well known that TOO LITTLE vitamin D is associated with health problems
TOO MUCH vitamin D may also be associated with health problems

Possible reasons include:

  1. Body is out of balance with too much vitamin D – consider adjusting cofactors
    CURE: Increase Vitamin K2
        - prevents excess Calcium created by lots of vitamin D from going to wrong places in body (arteries, prostate, etc)
    CURE: Increase Magnesium – which is vital for health but is consumed by Vitamin D
    CURE: Reduce Calcium – which may be in excess due to high level of vitamin D
  2. Large doses of vitamin D taken very infrequently (quarterly, yearly) is known to cause imbalance and problems
    CURE: Take vitamin more often than than once every 20 days
  3. The body might change the Vitamin D Binding Protein so as to increase vitamin D levels when sick
  4. Sick people had attempted to heal themselves by adding Vitamin D or visiting a sunny climate
  5. Result of excess Vitamin A reducing the benefits of Vitamin D in the blood
    CURE: Don't get your Vitamin D from cod liver oil - which appears to have too much Vitamin A
    It appears that only Nordic studies of mortality have found problems with high levels of vitamin D
  6. Drug dosage often assumes low Vitamin D, High vitamin D increases/decreases dose potency
    Example: Vitamin D can greatly amplify various Chemo drugs, making them deadly
    CURE: Have doctors adjust prescribed dosage when a patient is taking lots of vitamin D
  7. Some Drugs Deplete Magnesium
    People may increase their vitamin D levels too high so as to feel benefits even with Magnesium limitation
  8. Had been taking Vitamin D2 - which is known to cause problems
  9. J-Shaped does not acutally exist - it was due to old style of Vitamin D tests having too high of readings
    See PubMed item below on this page

See also VitaminDWiki

See also PubMed


No increase of mortality with high vitamin D levels (j-shaped) when tests are standardized – April 2017

The Reverse J-Shaped Association Between Serum Total 25-Hydroxyvitamin D Concentration and All-Cause Mortality: The Impact of Assay Standardization.
Am J Epidemiol. 2017 Apr 15;185(8):720-726. doi: 10.1093/aje/kww244.
Durazo-Arvizu RA, Dawson-Hughes B, Kramer H, Cao G, Merkel J, Coates PM, Sempos CT.

We evaluated the impact of standardizing the originally measured serum total 25-hydroxyvitamin D (25(OH)D) values from Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) on the association between 25(OH)D and rate of all-cause mortality. Values were standardized to the gold-standard laboratory method. Follow-up from 1990-2006 consisted of 15,099 participants aged at least 20 years at baseline, among whom there were 3,784 deaths. Relative risk of death was adjusted for age, sex, race/ethnicity, and season using Poisson regression.

Results were obtained for eight 25(OH)D (nmol/L) categories: <20 nmol/L, 20-29 nmol/L, 30-39 nmol/L, 40-49 nmol/L, 50-59 nmol/L, 60-74 nmol/L, 75-99 nmol/L (reference), and ≥100 nmol/L. Assay standardization dramatically shifted original 25(OH)D values toward zero. Accordingly, risk ≥120 nmol/L could not be evaluated (i.e., n = 7 and ndeaths = 2). Relative risk (95% confidence interval (CI)) <40 nmol/L remained significant (30-39 nmol/L: relative risk (RR) = 1.4 (95% CI: 1.1, 1.6); 20-29 nmol/L: RR = 1.6 (95% CI: 1.3, 1.9), and <20 nmol/L: RR = 2.1 (95% CI: 1.6, 2.7).
However, adjusted relative risk estimates for 25(OH)D levels ≥40 nmol/L were no longer significant (40-49 nmol/L: RR = 1.2 (95% CI: 0.99, 1.4); 50-59 nmol/L: RR = 1.2 (95% CI: 1.04, 1.4); 60-74 nmol/L: RR = 1.1 (95% CI: 0.94, 1.2); 75-99 nmol/L: RR = 1.0 (referent), and ≥100 nmol/L: RR = 1.1 (95% CI: 0.6, 2.1).

In summary, after standardization, risk of death from all causes increased with decreasing 25(OH)D <40 nmol/L, while there was no association with values in categories between 40 nmol/L and 120 nmol/L.

PMID: 28338905 DOI: 10.1093/aje/kww244 Publisher wants $42 for the PDF


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Is too much vitamin D bad – possible causes and cures        

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