Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
PLoS One. 2017 May 31;12(5):e0177722. doi: 10.1371/journal.pone.0177722. eCollection 2017.
Seong JM1, Yoon YS2,3, Lee KS2, Bae NY4, Gi MY5, Yoon H6.
40 items in category Iron and Vitamin D
- Iron deficiency is a cause of Vitamin D deficiency also reviews other forms of Iron
- Anemia 1.9X more likely in white children having lowish vitamin D – Jan 2014
- Anemia in pregnant teens 7X more likely if low vitamin D – April 2015
- Iron and Vitamin D deficiencies are synergistic - April 2015
- IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016
- Restless legs syndrome 3X more likely during pregnancy (low vitamin D) – Oct 2015
- Overview Iron Supplements and Vitamin D has the following table by Mercola
Diseases associated with
Low iron (menstruating) High iron (males) Anemia Anemia of chronic disease Fibromyalgia Premature aging Inflammatory bowel disease Atherosclerosis Hypothyroidism Anorexia Depression / anxiety Grave's disease Attention deficit hyperactivity disorder Heart arrhythmia Parkinson's disease Cancer Neurodegenerative conditions Sideroblastic anemia Celiac disease Nonalcoholic fatty liver disease (NAFLD).
Excess dietary fructose is a primary initiator of NAFLD,
but high iron is another culprit that triggers disease progression
Restless leg syndrome Liver damage and liver disease Hair loss Still's disease Muscle weakness, decline in motor skills Hemochromatosis Mental changes and memory loss Hemophagocytic syndrome
The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults.
A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL).
The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456).
Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women.
PMID: 28562685 PMCID: PMC5451000 DOI: 10.1371/journal.pone.0177722
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