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Inhaled vitamin D helped lungs of new-born (rats) – Dec 2016

Inhaled Vitamin D: A Novel Strategy to Enhance Neonatal Lung Maturation.

Lung. 2016 Dec;194(6):931-943. Epub 2016 Sep 10.
Taylor SK1, Sakurai R1, Sakurai T1, Rehan VK2.

VitaminDWiki comments
  • I had wondered if inhaled Vit. D would help some breathing problems
    Examples: Asthma, pneumonia, RTI, COPD, Tuberculosis
  • Being able to apply any treatment locally is typically better than treating the entire body
    Topical vitamin D can be applied topically to skin problems, for example
    Most portions of the body are able to locally convert Vitamin D into its active form
  • This was the only article in PubMed in Nov 2016 which discussed Inhaled vitamin D
  • It might be pretty easy to put vitamin D into the lungs by putting water-soluble Vitamin D into a vaporizer or nebulizer

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INTRODUCTION:
The physiologic vitamin D (VD), 1α,25(OH)2D3 (1,25D) is a local paracrine/autocrine effecter of fetal lung maturation. By stimulating alveolar type II cell and lipofibroblast proliferation and differentiation, parenterally administered 1,25D has been shown to enhance neonatal lung maturation; but due to the potential systemic side effects of the parenteral route, the translational value of these findings might be limited. To minimize the possibility of systemic toxicity, we examined the effects of VD on neonatal lung maturation, when delivered directly to lungs via nebulization.
METHODS:
One-day-old rat pups were administered three different doses of 1,25D and its physiologic precursor 25(OH)D (25D), or the diluent, via nebulization daily for 14 days. Pups were sacrificed for lung, kidneys, and blood collection to determine markers of lung maturation, and serum 25D and calcium levels.
RESULTS:
Compared to controls, nebulized 25D and 1,25D enhanced lung maturation as evidenced by the increased expression of markers of alveolar epithelial (SP-B, leptin receptor), mesenchymal (PPARγ, C/EBPα), and endothelial (VEGF, FLK-1) differentiation, surfactant phospholipid synthesis, and lung morphology without any significant increases in serum 25D and calcium levels.
CONCLUSIONS:
Inhaled VD is a potentially safe and effective novel strategy to enhance neonatal lung maturation.

PMID: 27614961 DOI: 10.1007/s00408-016-9939-3

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