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Idiopathic Epileptic children have low levels of vitamin D – Oct 2015

 
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Epilepsy appears to be treated by Vitamin D (starting 5,000 IU RCT) – Dec 2016

Vitamin D for the Treatment of Epilepsy: Basic Mechanisms, Animal Models and Clinical Trials
Front. Neurol. | doi: 10.3389/fneur.2016.00218
Kevin Pendo2 and Christopher M. DeGiorgio, MD1*
1University of California, USA
2Princeton, USA

There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D is actively under investigation as a potential intervention for epilepsy. Vitamin D is fat soluble steroid which shows promise in animal models of epilepsy. Basic research has shed light on the possible mechanisms by which Vitamin D may reduce seizures, and animal data support the efficacy of Vitamin D in rat and mouse models of epilepsy. Very little clinical data exists to support the treatment of human epilepsy with Vitamin D, but positive findings from preliminary clinical trials warrant larger Phase I and II clinical trials in order to more rigorously determine the potential therapeutic value of Vitamin D as a treatment for human epilepsy.

__From the end of the conclusion section""
"Recently, our group has received an IND for a Phase I study of Vitamin D3 in drug resistant epilepsy to study the safety, preliminary efficacy and potential cardiac benefits of Vitamin D3 5000 IU/day in drug resistant epilepsy."

 Download the PDF from VitaminDWiki


Vitamin D Deficiency in Children With Newly Diagnosed Idiopathic Epilepsy - Oct 2015

J Child Neurol October 2015 vol. 30 no. 11 1428-1432
Fatma Mujgan Sonmez, MD1⇑, Ahsen Donmez, MD2, Mehmet Namuslu, MD3
Metin Canbal, MD4, Emel Orun, MD2
1Department of Child Neurology, Turgut Ozal University, Ankara, Turkey
2Department of Pediatrics, Turgut Ozal University, Ankara, Turkey
3Department of Biochemistry, Turgut Ozal University, Ankara, Turkey
4Department of Family Medicine, Turgut Ozal University, Ankara, Turkey
Fatma Mujgan Sonmez, MD, Department of Child Neurology, Turgut Ozal University, Alparslan Turkes Caddesi, No: 57 Emek, Ankara 06560, Turkey. Email: mjgsonmez at yahoo.com

VitaminDWiki Summary

14 ng for newly diagnosed vs 23 ng for controls
Suspect that newly diagnosed have not had Vitamin D depleting drugs

Note:

  • Vitamin D appears to treat Epilepsy, and might prevent Epilepsy
  • Vitamin D is depleted by many epileptic drugs
  • People with Epilepsy should take vitamin D so as to avoid having health problems associated with low vitamin D, such as low bone density

See also VitaminDWiki

Note: CBD is extremely good at reducing epilepsy – one brand was named after a girl whose seizures deceases by ~20X after taking CBD (hemp oil). (Had purchased Charlotte's Web Hemp Extract in MCT Oil on Amazon Sept 2015 to relieve pain for my father-in-law)


Several studies have shown a link between vitamin D deficiency and epilepsy. This study includes 60 newly diagnosed idiopathic epilepsy patients and 101 healthy controls (between the ages of 5 and 16). Each group was also divided into two subgroups according to seasonal changes in terms of months of longer versus shorter daylight. We retrospectively evaluated the levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25-OH vitamin-D3 in the study participants. Levels below 20 ng/ml were defined as vitamin D deficiency and levels of 20-30 ng/ml as insufficiency. There were no significant differences in age, gender distribution and levels of calcium, phosphorus, alkaline phosphatase and parathyroid hormone between the groups. The level of 25-OH vitamin-D3 in the patient group was significantly lower when compared to the control group (p < 0.05) (14.07 ± 8.12 and 23.38 ± 12.80 ng/ml, respectively). This difference also held true when evaluation was made according to seasonal evaluation (12.38 ± 6.53 and 17.64 ± 1.14 in shorter daylight and 18.71 ± 9.87 and 30.82 ± 1.04 in longer daylight).

Publisher wants $36 for the PDF


Idiopathic Epilepsy at AboutKidsHealth

There are a variety of idiopathic epilepsy syndromes. Children with idiopathic epilepsy may have generalized or partial seizures.
Many, although not all, idiopathic epilepsy syndromes are benign and the child will eventually grow out of them.
Relatives of a child with idiopathic epilepsy often have a history of seizures.
What are other terms for idiopathic epilepsy?
An older term for idiopathic epilepsy is primary epilepsy. The terms “idiopathic epilepsy” and “cryptogenic epilepsy” are sometimes used interchangeably, especially in older books and articles.
What causes idiopathic epilepsy?
By definition, there is no apparent underlying cause of idiopathic epilepsy, such as a structural problem with the brain or a metabolic disorder. It is possible that idiopathic epilepsy is caused by tiny abnormalities at the cellular level. We are now learning that many, although not all, idiopathic epilepsy syndromes have an associated genetic component.
In most cases, the exact way in which epilepsy is inherited is unclear. However, some researchers estimate that genes could account for 70% to 90% of the tendency to develop epilepsy.
What epilepsy syndromes are idiopathic?

  • benign epilepsy of childhood with centrotemporal spikes (BECTS)
  • childhood epilepsy with occipital paroxysms
  • benign neonatal familial convulsions
  • benign neonatal convulsions
  • benign myoclonic epilepsy in infancy
  • childhood absence epilepsy
  • juvenile absence epilepsy
  • juvenile myoclonic epilepsy

How many other children have idiopathic epilepsy?
Idiopathic epilepsy is common; about 30% of childhood epilepsy is idiopathic.
Together, idiopathic and cryptogenic epilepsy account for 55% to 75% of cases of childhood epilepsy.
It is difficult to be precise, because different researchers define these terms differently.
How is idiopathic epilepsy treated?
Idiopathic epilepsy is treated with anti-epileptic drugs.
What is the outlook for a child with idiopathic epilepsy?
The outlook for a child with idiopathic epilepsy depends on the specific condition and how well the seizures respond to treatment.
Several idiopathic epilepsy syndromes, such as childhood absence epilepsy and BECTS, usually go away on their own.
With other syndromes, though, the child may need to take anti-epileptic drugs all his life.
Elizabeth J. Donner, MD, FRCPC, 2/4/2010


About one percent of Americans have some form of epilepsy, and nearly four percent (1 in 26) will develop epilepsy at some point in their lives. The number of Americans who have epilepsy is greater than the number who have multiple sclerosis, Parkinson's disease, and cerebral palsy combined.


 see also "Epidemiology of Idiopathic Generalized Epilepsies" - 2005 VitaminDWiki


See also PubMed

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  • Epilepsy and vitamin D: a comprehensive review of current knowledge Dec 2016, Behind a $42 paywall
    "In this article, we review the possible relationship between vitamin D and epilepsy from different aspects, including the action mechanism of vitamin D in the central nervous system and ecological and epidemiological findings. We also present the outcome of studies that evaluated the level of vitamin D and the impact of administrating vitamin D in epileptic patients or animal subjects"

See also web

Some graphics from the web

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CBD helps some people with Epilepsy

Update Dec 2016 - US Drug Enforcement Agency put CBD into the class of adidcting drugs which include cocaine - so CBD is unlikely to stiil be on Amazon

Suspect that there are several types of Epilepsy, and that not all benefit from CBD

Attached files

ID Name Comment Uploaded Size Downloads
7438 Epilepsy - 2016.pdf PDF 2016 admin 04 Dec, 2016 03:13 388.71 Kb 303
6446 3 month trial.jpg admin 03 Mar, 2016 03:57 28.51 Kb 1412
6445 Epilepsy prevalance increasing.jpg admin 03 Mar, 2016 03:26 15.91 Kb 1390
6444 epilepsy statistics.jpg admin 03 Mar, 2016 03:26 30.84 Kb 1185
6443 Causes of epilepsy.jpg admin 03 Mar, 2016 03:25 25.24 Kb 1894
6065 Epidemiology of Idiopathic Generalized Epilepsies.pdf PDF admin 18 Oct, 2015 23:19 68.36 Kb 560
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