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Epilepsy appears to be treated by Vitamin D (starting 5,000 IU RCT) – Dec 2016
Vitamin D for the Treatment of Epilepsy: Basic Mechanisms, Animal Models and Clinical Trials
Front. Neurol. | doi: 10.3389/fneur.2016.00218
Kevin Pendo2 and Christopher M. DeGiorgio, MD1*
1University of California, USA
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D is actively under investigation as a potential intervention for epilepsy. Vitamin D is fat soluble steroid which shows promise in animal models of epilepsy. Basic research has shed light on the possible mechanisms by which Vitamin D may reduce seizures, and animal data support the efficacy of Vitamin D in rat and mouse models of epilepsy. Very little clinical data exists to support the treatment of human epilepsy with Vitamin D, but positive findings from preliminary clinical trials warrant larger Phase I and II clinical trials in order to more rigorously determine the potential therapeutic value of Vitamin D as a treatment for human epilepsy.
__From the end of the conclusion section""
"Recently, our group has received an IND for a Phase I study of Vitamin D3 in drug resistant epilepsy to study the safety, preliminary efficacy and potential cardiac benefits of Vitamin D3 5000 IU/day in drug resistant epilepsy."
Vitamin D Deficiency in Children With Newly Diagnosed Idiopathic Epilepsy - Oct 2015
J Child Neurol October 2015 vol. 30 no. 11 1428-1432
Fatma Mujgan Sonmez, MD1⇑, Ahsen Donmez, MD2, Mehmet Namuslu, MD3
Metin Canbal, MD4, Emel Orun, MD2
1Department of Child Neurology, Turgut Ozal University, Ankara, Turkey
2Department of Pediatrics, Turgut Ozal University, Ankara, Turkey
3Department of Biochemistry, Turgut Ozal University, Ankara, Turkey
4Department of Family Medicine, Turgut Ozal University, Ankara, Turkey
Fatma Mujgan Sonmez, MD, Department of Child Neurology, Turgut Ozal University, Alparslan Turkes Caddesi, No: 57 Emek, Ankara 06560, Turkey. Email: mjgsonmez at yahoo.com
14 ng for newly diagnosed vs 23 ng for controls
Suspect that newly diagnosed have not had Vitamin D depleting drugs
- Vitamin D appears to treat Epilepsy, and might prevent Epilepsy
- Vitamin D is depleted by many epileptic drugs
- People with Epilepsy should take vitamin D so as to avoid having health problems associated with low vitamin D, such as low bone density
See also VitaminDWiki
- Epilepsy and deficiency of vitamin D and-or Magnesium – Feb 2013
- Children with epilepsy advised to take vitamin D – July 2013
- Epilepsy seizures reduced by 40 percent after vitamin D levels normalized – April 2012
- Diseases which are related due to vitamin D deficiency
- Hypothesis – UV treat epilepsy – Feb 2011
- Epilepsy associated with low vitamin D 37 years ago, but still fewer than 1 in 1000 take vitamin D – Feb 2016
- Epilepsy category listing has
7 items along with related searches
Note: CBD is extremely good at reducing epilepsy – one brand was named after a girl whose seizures deceases by ~20X after taking CBD (hemp oil). (Had purchased Charlotte's Web Hemp Extract in MCT Oil on Amazon Sept 2015 to relieve pain for my father-in-law)
Several studies have shown a link between vitamin D deficiency and epilepsy. This study includes 60 newly diagnosed idiopathic epilepsy patients and 101 healthy controls (between the ages of 5 and 16). Each group was also divided into two subgroups according to seasonal changes in terms of months of longer versus shorter daylight. We retrospectively evaluated the levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25-OH vitamin-D3 in the study participants. Levels below 20 ng/ml were defined as vitamin D deficiency and levels of 20-30 ng/ml as insufficiency. There were no significant differences in age, gender distribution and levels of calcium, phosphorus, alkaline phosphatase and parathyroid hormone between the groups. The level of 25-OH vitamin-D3 in the patient group was significantly lower when compared to the control group (p < 0.05) (14.07 ± 8.12 and 23.38 ± 12.80 ng/ml, respectively). This difference also held true when evaluation was made according to seasonal evaluation (12.38 ± 6.53 and 17.64 ± 1.14 in shorter daylight and 18.71 ± 9.87 and 30.82 ± 1.04 in longer daylight).
Idiopathic Epilepsy at AboutKidsHealth
There are a variety of idiopathic epilepsy syndromes. Children with idiopathic epilepsy may have generalized or partial seizures.
Many, although not all, idiopathic epilepsy syndromes are benign and the child will eventually grow out of them.
Relatives of a child with idiopathic epilepsy often have a history of seizures.
What are other terms for idiopathic epilepsy?
An older term for idiopathic epilepsy is primary epilepsy. The terms “idiopathic epilepsy” and “cryptogenic epilepsy” are sometimes used interchangeably, especially in older books and articles.
What causes idiopathic epilepsy?
By definition, there is no apparent underlying cause of idiopathic epilepsy, such as a structural problem with the brain or a metabolic disorder. It is possible that idiopathic epilepsy is caused by tiny abnormalities at the cellular level. We are now learning that many, although not all, idiopathic epilepsy syndromes have an associated genetic component.
In most cases, the exact way in which epilepsy is inherited is unclear. However, some researchers estimate that genes could account for 70% to 90% of the tendency to develop epilepsy.
What epilepsy syndromes are idiopathic?
- benign epilepsy of childhood with centrotemporal spikes (BECTS)
- childhood epilepsy with occipital paroxysms
- benign neonatal familial convulsions
- benign neonatal convulsions
- benign myoclonic epilepsy in infancy
- childhood absence epilepsy
- juvenile absence epilepsy
- juvenile myoclonic epilepsy
How many other children have idiopathic epilepsy?
Idiopathic epilepsy is common; about 30% of childhood epilepsy is idiopathic.
Together, idiopathic and cryptogenic epilepsy account for 55% to 75% of cases of childhood epilepsy.
It is difficult to be precise, because different researchers define these terms differently.
How is idiopathic epilepsy treated?
Idiopathic epilepsy is treated with anti-epileptic drugs.
What is the outlook for a child with idiopathic epilepsy?
The outlook for a child with idiopathic epilepsy depends on the specific condition and how well the seizures respond to treatment.
Several idiopathic epilepsy syndromes, such as childhood absence epilepsy and BECTS, usually go away on their own.
With other syndromes, though, the child may need to take anti-epileptic drugs all his life.
Elizabeth J. Donner, MD, FRCPC, 2/4/2010
About one percent of Americans have some form of epilepsy, and nearly four percent (1 in 26) will develop epilepsy at some point in their lives. The number of Americans who have epilepsy is greater than the number who have multiple sclerosis, Parkinson's disease, and cerebral palsy combined.
See also PubMed
- Bone Health and Vitamin D Status in Young Epilepsy Patients on Valproate Monotherapy April 2016
"Prevalence of low BMD (Z-score ≤−2.0) was 26% and 10% at lumbar spine, and 10% and 4% at femoral neck in epileptic and control groups respectively. No correlation was found between duration or dosage of VPA and BMDs. Vitamin D deficiency (≤20 ng/ml) was highly prevalent (>90%) in epilepsy patients and controls."
- The roles of vitamin B12 and vitamin D in children with intractable epilepsy Jan 2015
"a clear association between vitamin D and vitamin B12 treatment and epilepsy was identified" full free text online
- Low vitamin D levels are common in patients with epilepsy Oct 2014
Due to antiepileptic drugs. full free text online
- Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study May 2012
"Median seizure reduction was 40%"
Loading dose then maintenance dose of 2000 to 2600 IU daily
- Epilepsy and vitamin D: a comprehensive review of current knowledge Dec 2016, Behind a $42 paywall
"In this article, we review the possible relationship between vitamin D and epilepsy from different aspects, including the action mechanism of vitamin D in the central nervous system and ecological and epidemiological findings. We also present the outcome of studies that evaluated the level of vitamin D and the impact of administrating vitamin D in epileptic patients or animal subjects"
See also web
- http://www.epilepsy.org.au/resources/for-media/facts-statistics-about-epilepsy has such factoids as:
According to the World Health Organisation, epilepsy is the world's most common serious brain disorder
Epilepsy is more than three times as common as multiple sclerosis, Parkinson’s disease and cerebral palsy
It is commonly thought that epilepsy always involves convulsions.
In fact there are around 40 different types of epilepsy and epilepsy syndromes.
"More people live with epilepsy than with autism spectrum disorders, Parkinson’s disease, multiple sclerosis and cerebral palsy combined"
- Children with epilepsy advised to take vitamin D July 2013
But only enough vitamin D to deal with bone loss problems, not treat Epilepsy
Some graphics from the web
CBD helps some people with Epilepsy
Update Dec 2016 - US Drug Enforcement Agency put CBD into the class of adidcting drugs which include cocaine - so CBD is unlikely to stiil be on Amazon
- Marijuana Use in Epilepsy: The Myth and the Reality Aug 2015
Behind a paywall, but patients can get copy of PDF for free
CBD is legal (vs THC) and is sold on Amazon.
One brand of CBD was named after the girl who's seizures reduced from 300/month to 1/month
- Cannabis helps my epileptic son. If only we had known sooner April 2016
Mother had refined Cannabis to make CBD,
Incorrectly believes that govt does not permit it,
- Can Cannabis Treat Epileptic Seizures? Scientific American Jan 2016
"Stories of cannabis’s abilities to alleviate seizures have been around for about 150 years . . "
"The researchers reported the intervention reduced motor seizures at a rate similar to existing drugs (a median of 36.5 percent) and 2 percent of patients became completely seizure free. Additionally, 79 percent of patients reported adverse effects such as sleepiness, diarrhea and fatigue, although only 3 percent dropped out of the study due to adverse events. "
- Update Dec 2016 US Drug Enforcement Angencyt has classifiedCBD as bad as Cocaine, heroin etc
Note: I am unaware of any cases of CBD addiction
Link has a 219 pages of studies showing the benefits of CBD
Suspect that there are several types of Epilepsy, and that not all benefit from CBD
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ID Name Comment Uploaded Size Downloads 7438 Epilepsy - 2016.pdf PDF 2016 admin 2016-12-04 03:13 388.71 Kb 162 6446 3 month trial.jpg admin 2016-03-03 03:57 28.51 Kb 982 6445 Epilepsy prevalance increasing.jpg admin 2016-03-03 03:26 15.91 Kb 974 6444 epilepsy statistics.jpg admin 2016-03-03 03:26 30.84 Kb 883 6443 Causes of epilepsy.jpg admin 2016-03-03 03:25 25.24 Kb 1389 6065 Epidemiology of Idiopathic Generalized Epilepsies.pdf admin 2015-10-18 23:19 68.36 Kb 454