Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.
J Physiol. 2017 Nov 15;595(22):6825-6836. doi: 10.1113/JP274887. Epub 2017 Oct 31.
Berridge MJ The Babraham Institute, Cambridge, CB22 3AT, UK.
Autophagy, Inflammation, Mitochondrial dysfunction, Oxidative stress, Ca2+ signalling, Epigenetics, DNA disorders
- Seniors who feel healthier have higher levels of vitamin D (30 ng) – Nov 2016
- Many diseases of aging are associated with low vitamin D – Dec 2014
- Supplements to Take in Your 50s, 60s and 70s (vitamin D is the only 1 in all 3) - AARP Dec 2014
- Aging leads to a decrease of vitamin D getting to cells – Sept 2017
Alzheimers-Cognition - Overview has the following summary
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s 21 % more likely if low vitamin D
- FACT: Alzheimer's Disease is 4X less likely if less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Several vitamin D lNTERVENTION clinical trials - 64 as of Oct 2017
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should start taking vitamin D
Additional supplements to be considered include Omega-3 and Magnesium
- All items in category Cognition and vitamin D
Ageing can occur at different rates, but what controls this variable rate is unknown. Here I have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis of this hypothesis emerged from studyng the various cellular processes that control ageing. These processes such as autophagy, mitochondrial dysfunction, inflammation, oxidative stress, epigenetic changes, DNA disorders and alterations in Ca2+ and reactive oxygen species (ROS) signalling are all known to be regulated by vitamin D. The activity of these processes will be enhanced in individuals that are deficient in vitamin D.
Not only will this increase the rate of ageing, but it will also increase the probability of developing age-related diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and cardiovascular disease.
In individual with normal vitamin D levels, these ageing-related processes will occur at lower rates resulting in a reduced rate of ageing and enhanced protection against these age-related diseases.
PMID: 28949008 DOI: 10.1113/JP274887
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