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High intracranial pressure in children – most common cause was low vitamin D – March 2015

Intracranial Hypertension in Children: Etiologies, Clinical Features, and Outcome.

J Child Neurol. 2015 Mar 11. pii: 0883073815574332. [Epub ahead of print]
Masri A1, Jaafar A2, Noman R3, Gharaibeh A4, Ababneh OH4.
1Faculty of Medicine, Division of Child Neurology, Department of Pediatrics, University of Jordan, Amman, Jordan masriamira69 at hotmail.com.
2Faculty of Medicine, Department of Pediatrics, University of Jordan, Amman, Jordan.
3Faculty of Medicine, Resident Department of Pediatrics, University of Jordan, Amman, Jordan.
4Faculty of Medicine, Department of Ophthalmology, University of Jordan and Jordan University Hospital, Amman, Jordan.

This retrospective study aimed to describe the clinical presentations, possible causes, and outcomes of children with idiopathic intracranial hypertension who presented to the authors' clinic. The mean age at onset of symptoms in the authors' cohort of 19 children was 6 years (range: 7 months to 12 years). Most patients (90%) were under 11 years old and (84.2%) symptomatic. The probable cause was identified in 7/19 (37.0%) patients. The most common cause was vitamin D deficiency (26.3%). Other associated probably coincidental comorbidities included sinusitis (5/19, 26.3%), hypophosphatasia (1/19), Pyle disease (1/19), and measles vaccine (1/19). Apart from 2 patients who required lumboperitoneal shunt, the cerebrospinal fluid pressure returned to normal in all patients within a period of 6 weeks to 1 year (average, 5 months). Of those who followed up with the authors' ophthalmologist, 30.7% developed optic atrophy or pallor; 75% of these patients had previous ocular comorbidities.

PMID: 25762586