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Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems problems – 2015

Both gene problems cause less Vitamin D to be available in the body

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Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients - March 2015 (50%)

BioMed Research International, Volume 2015 (2015), Article ID 625981, 7 pg, http://dx.doi.org/10.1155/2015/625981
Muzaffer Ilhan,1 Bahar Toptas-Hekimoglu,2 Ilhan Yaylim,2 Seda Turgut,3 Saime Turan,2 Ozcan Karaman,1 and Ertugrul Tasan1
1Department of Endocrinology and Metabolism, Bezmialem University, 34093 Istanbul, Turkey
2Department of Molecular Medicine, The Institute of Experimental Medicine, 34093 Istanbul, Turkey
3Department of Internal Medicine, Bezmialem University, 34093 Istanbul, Turkey

Objective. The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly.

Design, Patients, and Methods. 52 acromegaly patients (mean age 46 years) and 83 controls (mean age 47 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods.

Results. The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (P =0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (P = 0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07–2.1; ). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff genotype (P=0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (P=0.0001).

Conclusions. Our study suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the course of acromegaly as a consequence of altering hormonal status.

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Vitamin D-binding protein and free vitamin D concentrations in acromegaly - Nov 2015

Alev Eroglu Altinova, Cigdem Ozkan cozkan34 at hotmail.com , Mujde Akturk, Ozlem Gulbahar, Muhittin Yalcin, Nuri Cakir, Fusun Balos Toruner

Free 25-hydroxyvitamin D [25(OH)D] is suggested to be important in the determination of vitamin D deficiency, since vitamin D-binding protein (VDBP) may affect total 25(OH)D levels. There are no data about free 25(OH)D concentrations in acromegaly. We aimed to investigate serum VDBP and total and free 25(OH)D levels in patients with acromegaly in comparison with control subjects. We recruited 54 patients with acromegaly and 32 control subjects who were similar according to age, gender, and body mass index. Serum VDBP levels were found to be increased in patients with acromegaly compared to control subjects [90.35 (72.45–111.10) vs. 69.52 (63.89–80.13) mg/l, p = 0.001]. There was statistically no significant difference in serum total 25(OH)D levels between the patients with acromegaly and control subjects [18.63 (13.35–27.73) vs. 22.51 (19.20–28.96) ng/ml, p = 0.05]. Free 25(OH)D levels were significantly decreased in patients with acromegaly compared to control subjects [14.55 (10.45–21.45) vs. 17.75 (15.30–23.75) pg/ml, p = 0.03]. Free 25(OH)D levels correlated positively with total 25(OH)D (p = 0.0001) and HDL cholesterol (p = 0.04) and negatively with fasting blood glucose (p = 0.04). Our findings indicate that VDBP is increased and free 25(OH)D is decreased in acromegaly, while there is no significant alteration in total 25(OH)D.

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See also web

  • Wikipedia
    "In over 90 percent of acromegaly patients, the overproduction of growth hormones is caused by a benign tumor of the pituitary gland, called an adenoma. "



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Attached files

ID Name Comment Uploaded Size Downloads
8679 Acromegaly T1.jpg admin 09 Nov, 2017 22:29 90.12 Kb 18
5153 625981.pdf PDF 2015 admin 08 Mar, 2015 18:05 1.14 Mb 455
5152 Andre 2.jpg admin 08 Mar, 2015 18:02 17.68 Kb 33946
5151 Andre.jpg admin 08 Mar, 2015 18:02 33.89 Kb 3224
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