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Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems problems – 2015

Both gene problems cause less Vitamin D to be available in the body

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Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients - March 2015 (50%)

BioMed Research International, Volume 2015 (2015), Article ID 625981, 7 pg, http://dx.doi.org/10.1155/2015/625981
Muzaffer Ilhan,1 Bahar Toptas-Hekimoglu,2 Ilhan Yaylim,2 Seda Turgut,3 Saime Turan,2 Ozcan Karaman,1 and Ertugrul Tasan1
1Department of Endocrinology and Metabolism, Bezmialem University, 34093 Istanbul, Turkey
2Department of Molecular Medicine, The Institute of Experimental Medicine, 34093 Istanbul, Turkey
3Department of Internal Medicine, Bezmialem University, 34093 Istanbul, Turkey

Objective. The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly.

Design, Patients, and Methods. 52 acromegaly patients (mean age 46 years) and 83 controls (mean age 47 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods.

Results. The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (P =0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (P = 0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07–2.1; ). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff genotype (P=0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (P=0.0001).

Conclusions. Our study suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the course of acromegaly as a consequence of altering hormonal status.

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Vitamin D-binding protein and free vitamin D concentrations in acromegaly - Nov 2015

Alev Eroglu Altinova, Cigdem Ozkan cozkan34 at hotmail.com , Mujde Akturk, Ozlem Gulbahar, Muhittin Yalcin, Nuri Cakir, Fusun Balos Toruner

Free 25-hydroxyvitamin D [25(OH)D] is suggested to be important in the determination of vitamin D deficiency, since vitamin D-binding protein (VDBP) may affect total 25(OH)D levels. There are no data about free 25(OH)D concentrations in acromegaly. We aimed to investigate serum VDBP and total and free 25(OH)D levels in patients with acromegaly in comparison with control subjects. We recruited 54 patients with acromegaly and 32 control subjects who were similar according to age, gender, and body mass index. Serum VDBP levels were found to be increased in patients with acromegaly compared to control subjects [90.35 (72.45–111.10) vs. 69.52 (63.89–80.13) mg/l, p = 0.001]. There was statistically no significant difference in serum total 25(OH)D levels between the patients with acromegaly and control subjects [18.63 (13.35–27.73) vs. 22.51 (19.20–28.96) ng/ml, p = 0.05]. Free 25(OH)D levels were significantly decreased in patients with acromegaly compared to control subjects [14.55 (10.45–21.45) vs. 17.75 (15.30–23.75) pg/ml, p = 0.03]. Free 25(OH)D levels correlated positively with total 25(OH)D (p = 0.0001) and HDL cholesterol (p = 0.04) and negatively with fasting blood glucose (p = 0.04). Our findings indicate that VDBP is increased and free 25(OH)D is decreased in acromegaly, while there is no significant alteration in total 25(OH)D.

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  • 1.L. Lieben, G. Carmeliet, R. Masuyama, Calcemic actions of vitamin D: effects on the intestine, kidney and bone. Best Pract. Res. Clin. Endocrinol. Metab. 25, 561–572 (2011)CrossRefPubMed
  • 2.A.R. Menezes, M.C. Lamb, C.J. Lavie, J.J. DiNicolantonio, Vitamin D and atherosclerosis. Curr. Opin. Cardiol. 29, 571–577 (2014)CrossRefPubMed
  • 3.Y. Song, L. Wang, A.G. Pittas, L.C. Del Gobbo, C. Zhang, J.E. Manson, F.B. Hu, Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 36, 1422–1428 (2013)PubMed CentralCrossRefPubMed
  • 4.J.P. Forman, G.C. Curhan, E.N. Taylor, Plasma 25-hydroxy vitamin D levels and risk of incident hypertension among young women. Hypertension 52, 828–832 (2008)PubMed CentralCrossRefPubMed
  • 5.C. Berg, S. Petersenn, H. Lahner, B.L. Herrmann, M. Buchfelder, M. Droste, G.K. Stalla, C.J. Strasburger, U. Roggenbuck, N. Lehmann, S. Moebus, K.H. Jockel, S. Mohlenkamp, R. Erbel, B. Saller, K. Mann, Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. J. Clin. Endocrinol. Metab. 95, 3648–3656 (2010)CrossRefPubMed
  • 6.G. Mazziotti, E. Biagioli, F. Maffezzoni, M. Spinello, V. Serra, R. Maroldi, I. Floriani, A. Giustina, Bone turnover, bone mineral density, and fracture risk in acromegaly: a meta-analysis. J. Clin. Endocrinol. Metab. 100, 384–394 (2015)CrossRefPubMed
  • 7.S. Takamoto, H. Tsuchiya, T. Onishi, S. Morimoto, S. Imanaka, S. Mori, Y. Seino, T. Uozumi, Y. Kumahara, Changes in calcium homeostasis in acromegaly treated by pituitary adenomectomy. J. Clin. Endocrinol. Metab. 61, 7–11 (1985)CrossRefPubMed
  • 8.S. Bonadonna, G. Mazziotti, M. Nuzzo, A. Bianchi, A. Fusco, L. De Marinis, A. Giustina, Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women. J. Bone Miner. Res. 20, 1837–1844 (2005)CrossRefPubMed
  • 9.P. Kamenicky, A. Blanchard, C. Gauci, S. Salenave, A. Letierce, M. Lombes, S. Brailly-Tabard, M. Azizi, D. Prie, J.C. Souberbielle, P. Chanson, Pathophysiology of renal calcium handling in acromegaly: what lies behind hypercalciuria? J. Clin. Endocrinol. Metab. 97, 2124–2133 (2012)CrossRefPubMed
  • 10.J. Halupczok-Zyla, A. Jawiarczyk-Przybylowska, M. Bolanowski, Patients with active acromegaly are at high risk of 25(OH)D deficiency. Front. Endocrinol. (Lausanne) 6, 89 (2015)
  • 11.A.J. Brown, D.W. Coyne, Bioavailable vitamin D in chronic kidney disease. Kidney Int. 82, 5–7 (2012)CrossRefPubMed
  • 12.J.B. Schwartz, J. Lai, B. Lizaola, L. Kane, S. Markova, P. Weyland, N.A. Terrault, N. Stotland, D. Bikle, A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J. Clin. Endocrinol. Metab. 99, 1631–1637 (2014)PubMed CentralCrossRefPubMed
  • 13.D.D. Bikle, E. Gee, B. Halloran, M.A. Kowalski, E. Ryzen, J.G. Haddad, Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J. Clin. Endocrinol. Metab. 63, 954–959 (1986)CrossRefPubMed
  • 14.H.Q. Ying, H.L. Sun, B.S. He, Y.Q. Pan, F. Wang, Q.W. Deng, J. Chen, X. Liu, S.K. Wang, Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer. Sci. Rep. 5, 7956 (2015)PubMed CentralCrossRefPubMed
  • 15.L. Kane, K. Moore, D. Lutjohann, D. Bikle, J.B. Schwartz, Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J. Clin. Endocrinol. Metab. 98, 4400–4409 (2013)PubMed CentralCrossRefPubMed
  • 16.P. Glendenning, G.T. Chew, C.A. Inderjeeth, M. Taranto, W.D. Fraser, Calculated free and bioavailable vitamin D metabolite concentrations in vitamin D-deficient hip fracture patients after supplementation with cholecalciferol and ergocalciferol. Bone 56, 271–275 (2013)CrossRefPubMed
  • 17.A.P. Ashraf, C. Huisingh, J.A. Alvarez, X. Wang, B.A. Gower, Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J. Clin. Endocrinol. Metab. 99, 178–183 (2014)PubMed CentralCrossRefPubMed
  • 18.R.F. Chun, B.E. Peercy, E.S. Orwoll, C.M. Nielson, J.S. Adams, M. Hewison, Vitamin D and DBP: the free hormone hypothesis revisited. J. Steroid Biochem. Mol. Biol. 144, 132–137 (2014)CrossRefPubMed
  • 19.M.S. Johnsen, G. Grimnes, Y. Figenschau, P.A. Torjesen, B. Almas, R. Jorde, Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D. Scand. J. Clin. Lab. Investig. 74, 177–183 (2014)CrossRef
  • 20.C.E. Powe, C. Ricciardi, A.H. Berg, D. Erdenesanaa, G. Collerone, E. Ankers, J. Wenger, S.A. Karumanchi, R. Thadhani, I. Bhan, Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J. Bone Miner. Res. 26, 1609–1616 (2011)PubMed CentralCrossRefPubMed
  • 21.A. Giustina, P. Chanson, M.D. Bronstein, A. Klibanski, S. Lamberts, F.F. Casanueva, P. Trainer, E. Ghigo, K. Ho, S. Melmed, A consensus on criteria for cure of acromegaly. J. Clin. Endocrinol. Metab. 95, 3141–3148 (2010)CrossRefPubMed
  • 22.L. Katznelson, J.L. Atkinson, D.M. Cook, S.Z. Ezzat, A.H. Hamrahian, K.K. Miller, American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly–2011 update: executive summary. Endocr. Pract. 17, 636–646 (2011)CrossRefPubMed
  • 23.American Diabetes Association, Classification and diagnosis of diabetes. Diabetes Care 38, S8–S16 (2015)CrossRef
  • 24.P.A. James, S. Oparil, B.L. Carter, W.C. Cushman, C. Dennison-Himmelfarb, J. Handler, D.T. Lackland, M.L. LeFevre, T.D. MacKenzie, O. Ogedegbe, S.C. Smith Jr, L.P. Svetkey, S.J. Taler, R.R. Townsend, J.T. Wright Jr, A.S. Narva, E. Ortiz, 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311, 507–520 (2014)CrossRefPubMed
  • 25.Third Report of the National Cholesterol Education Program (NCEP), Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III) final report. Circulation 106, 3143–3421 (2002)
  • 26.M.M. Speeckaert, R. Speeckaert, N. van Geel, J.R. Delanghe, Vitamin D binding protein: a multifunctional protein of clinical importance. Adv. Clin. Chem. 63, 1–57 (2014)CrossRefPubMed
  • 27.R.F. Chun, New perspectives on the vitamin D binding protein. Cell Biochem. Funct. 30, 445–456 (2012)CrossRefPubMed
  • 28.P. Yousefzadeh, S.A. Shapses, X. Wang, Vitamin D binding protein impact on 25-hydroxyvitamin D levels under different physiologic and pathologic conditions. Int. J. Endocrinol. 2014, 981581 (2014)PubMed CentralCrossRefPubMed
  • 29.Z. Dastani, C. Berger, L. Langsetmo, L. Fu, B.Y. Wong, S. Malik, D. Goltzman, D.E. Cole, J.B. Richards, In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations. J. Bone Miner. Res. 29, 494–499 (2014)CrossRefPubMed
  • 30.J. Aloia, M. Mikhail, R. Dhaliwal, A. Shieh, G. Usera, A. Stolberg, L. Ragolia, S. Islam, Free 25(OH)D and the vitamin D paradox in African Americans. J. Clin. Endocrinol. Metab. 100, 3356–3363 (2015)CrossRefPubMed
  • 31.A. Vitezova, M.C. Zillikens, T.T. van Herpt, E.J. Sijbrands, A. Hofman, A.G. Uitterlinden, O.H. Franco, J.C. Kiefte-de Jong, Vitamin D status and metabolic syndrome in the elderly: the Rotterdam Study. Eur. J. Endocrinol. 172, 327–335 (2015)CrossRefPubMed
  • 32.A. Tsur, B.S. Feldman, I. Feldhammer, M.B. Hoshen, G. Leibowitz, R.D. Balicer, Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care 36, 1361–1367 (2013)PubMed CentralCrossRefPubMed
  • 33.N.M. van Schoor, M. Visser, S.M. Pluijm, N. Kuchuk, J.H. Smit, P. Lips, Vitamin D deficiency as a risk factor for osteoporotic fractures. Bone 42, 260–266 (2008)CrossRefPubMed
  • 34.R. Shah, A. Licata, N.M. Oyesiku, A.G. Ioachimescu, acromegaly as a cause of 1,25-dihydroxyvitamin D-dependent hypercalcemia: case reports and review of the literature. Pituitary 15(Suppl 1), S17–S22 (2012)CrossRefPubMed
  • 35.P. Ameri, A. Giusti, M. Boschetti, G. Murialdo, F. Minuto, D. Ferone, Interactions between vitamin D and IGF-I: from physiology to clinical practice. Clin. Endocrinol. (Oxf) 79, 457–463 (2013)CrossRef
  • 36.A. Ajmal, A. Haghshenas, S. Attarian, M. Barake, N.A. Tritos, A. Klibanski, K.K. Miller, L.B. Nachtigall, The effect of somatostatin analogs on vitamin D and calcium concentrations in patients with acromegaly. Pituitary 17, 366–373 (2014)CrossRefPubMed

See also web

  • Wikipedia
    "In over 90 percent of acromegaly patients, the overproduction of growth hormones is caused by a benign tumor of the pituitary gland, called an adenoma. "

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ID Name Comment Uploaded Size Downloads
8679 Acromegaly T1.jpg admin 09 Nov, 2017 22:29 90.12 Kb 68
5153 625981.pdf PDF 2015 admin 08 Mar, 2015 18:05 1.14 Mb 483
5152 Andre 2.jpg admin 08 Mar, 2015 18:02 17.68 Kb 34217
5151 Andre.jpg admin 08 Mar, 2015 18:02 33.89 Kb 3272
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