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Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017

Pre-pregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: a prospective cohort study

Journal of Diabetes, online: 4 October 2017, DOI: 10.1111/1753-0407.12611
Wei Bao,Yiqing Song, Kimberly A. Bertrand, Deirdre K. Tobias, Sjurdur F. Olsen, Jorge E. Chavarro, James L. Mills, Frank B. Hu, Cuilin Zhang

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Background
Vitamin D may play a pivotal role in regulating insulin secretion and insulin sensitivity. However, the impact of vitamin D intake either from diet or from supplements on the development of gestational diabetes mellitus (GDM) remains unknown. We prospectively examined the association of pre-pregnancy habitual intake of vitamin D from diet and supplements with risk of incident GDM in a well-established cohort.

Methods
We included 21,356 singleton pregnancies from 15,225 women in the Nurses' Health Study II cohort. Diet information, including vitamin D intakes from food sources and supplements, was assessed in 1991 and every four years thereafter by validated food frequency questionnaires. We used log-binomial models with generalized estimating equations to estimate the relative risks (RRs) and 95% confidence intervals (CIs).

Results
We documented 865 incident GDM cases during 10 years of follow-up. After adjustment for age, parity, race/ethnicity, family history of diabetes, dietary and lifestyle factors, and body mass index, the RRs (95% CIs) of GDM risk associated with supplemental vitamin D intake of 0, 1–399, ≥ 400 IU/d were 1.00 (reference), 0.80 (0.67-0.96), and 0.71 (0.56-0.90), respectively (P for trend = 0.002). Dietary and total vitamin D intakes were also inversely associated with GDM risk, but the associations were not statistically significant.

Conclusions
Pre-pregnancy supplemental vitamin D intake was significantly and inversely associated with risk of GDM. Our study indicates potential benefits of increasing vitamin D intake from supplements in the prevention of GDM in women of reproductive age.

Created by admin. Last Modification: Wednesday October 4, 2017 16:10:55 UTC by admin. (Version 3)

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8513 GD 400 IU.pdf PDF 2017 admin 04 Oct, 2017 16:04 1.02 Mb 25
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