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Gastric Cancer 8.8 times more likely if low vitamin D – Sept 2016

Second study on this page shows that increased stage of Gastric Cancer is associated with decreased vitamin D levels

Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis.

World J Gastrointest Oncol. 2016 Sep 15;8(9):688-94. doi: 10.4251/wjgo.v8.i9.688.
Vyas N1, Companioni RC1, Tiba M1, Alkhawam H1, Catalano C1, Sogomonian R1, Baum J1, Walfish A1.
1Neil Vyas, Hassan Alkhawam, Carmine Catalano, Robert Sogomonian, Department of Internal Medicine, Elmhurst Hospital Center, Elmhurst, NY 11373, United States.


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AIM:
To determine whether there is an increased risk of gastric adenocarcinoma associated with vitamin D deficiency (VDd).
METHODS:
A retrospective case control study was performed of all patients diagnosed with gastric adenocarcinoma between 2005 and 2015. After we excluded the patients without a documented vitamin D level, 49 patients were included in our study.
RESULTS:
The average age of patients with gastric adenocarcinoma and documented vitamin D level was 64 years old (95%CI: 27-86) and average vitamin D level was 20.8 mg/dL (95%CI: 4-44). Compared to a matched control group, the prevalence of VDd/insufficiency in patients with gastric adenocarcinoma was significantly higher than normal vitamin D levels (83.7% vs 16.3%). Forty-one patients (83.7%) with adenocarcinoma showed VDd/insufficiency compared to 18 (37%) patients with normal vitamin D level without gastric cancer (OR: 8.8, 95%CI: 5-22, P value < 0.0001). The average age of males with gastric adenocarcinoma diagnosis was 60 years old vs 68 years old for females (P = 0.01). Stage II gastric adenocarcinoma was the most prevalent in our study (37%).
CONCLUSION:
We reported a positive relationship between VDd and gastric adenocarcinoma, that is to say, patients with decreased VDd levels have an increased propensity for gastric adenocarcinoma.

PMID: 27672427 DOI: 10.4251/wjgo.v8.i9.688


Vitamin D in Different Stages of Gastric Cancer - 2016

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Attached files

ID Name Comment Uploaded Size Downloads
7740 GC stages.jpg admin 20 Feb, 2017 20:50 47.51 Kb 59
7739 Gastric Cancer.pdf PDF 2016 admin 20 Feb, 2017 20:44 96.02 Kb 35
7112 Gastric 2016.pdf PDF 2016 admin 28 Sep, 2016 15:28 957.99 Kb 64
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