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Few Fractures if high Magnesium intake – 2X fewer for men, 2.6X for women – June 2017

Dietary magnesium intake and fracture risk: data from a large prospective study.

Br J Nutr. 2017 Jun 20:1-7. doi: 10.1017/S0007114517001350. [Epub ahead of print]

Veronese N1, Stubbs B2, Solmi M3, Noale M1, Vaona A4, Demurtas J5, Maggi S1.
1 National Research Council, Neuroscience Institute, Aging Branch,35128, Padova,Italy.
2 Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill,London SE5 8AZ,UK.
3 Institute for Clinical Research and Education in Medicine (IREM),35128, Padova,Italy.
4 Primary Care Department,Azienda ULSS20 Verona, 37122,Verona,Italy.
5 Primary Care Department,Azienda USL Toscana Sud Est, 58042,Grosseto,Italy.

For women: More Magnesium ==> fewer fractures

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Research considering the relationship between dietary Mg and osteoporosis as well as fractures are sparse and conflicting. We therefore aimed to investigate Mg intake and the onset of fractures in a large cohort of American men and women involved in the Osteoarthritis Initiative over a follow-up period of 8 years. Dietary Mg intake (including that derived from supplementation) was evaluated through a FFQ at baseline and categorised using sex-specific quintiles (Q); osteoporotic fractures were evaluated through self-reported history. Overall, 3765 participants (1577 men; 2071 women) with a mean age of 60·6 (sd 9·1) years were included. During follow-up, 560 individuals (198 men and 368 women) developed a new fracture.

After adjusting for fourteen potential confounders at baseline and taking those with lower Mg intake as reference (Q1), men (hazard ratio (HR) 0·47; 95 % CI 0·21, 1·00, P=0·05) and women (HR 0·38; 95 % CI 0·17, 0·82, P=0·01) in the highest quintile reported a significantly lower risk for fracture.

Women meeting the recommended Mg intake were at a 27 % decreased risk for future fractures. In conclusion, higher dietary Mg intake has a protective effect on future osteoporotic fractures, especially in women with a high risk for knee osteoarthritis. Those women meeting the recommended Mg intake appear to be at a lower risk for fractures.

PMID: 28631583 DOI: 10.1017/S0007114517001350

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Created by admin. Last Modification: Sunday July 16, 2017 18:17:16 UTC by admin. (Version 9)

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