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Familial Mediterranean Fever is 3X more likely if poor Vitamin D Receptors (males) – Sept 2017

Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever.

Bosn J Basic Med Sci. 2017 Sep 18. doi: 10.17305/bjbms.2017.2259. [Epub ahead of print]
Turhan T1, Doğan HO, Boğdaycioğlu N, Eyerci N, Omma A, Sari İ, Yeşilyurt A, Karaaslan Y.
Department of Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey. amcaturhan at gmail.com.

VitaminDWiki

Vitamin D Receptor category has the following

173 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 37 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


 Download the PDF from VitaminDWiki

Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic inflammatory disorders. We aimed to investigate the concentrations of serum 25(OH)D3, lipid parameters, and three known VDR polymorphisms (BsmI, FokI, and TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF patients and 105 controls.

A total of 38 patients were in acute attacks at the time of investigation. Serum 25(OH)D3 concentrations were determined using liquid chromatography-tandem mass spectrometry. BsmI, FokI, and TaqI polymorphisms were analyzed by a competitive allele specific polymerase chain reaction assay (KASPar). Serum lipid parameters were measured with enzymatic colorimetric methods. 25(OH)D3 concentrations were lower in FMF patients compared to controls (p < 0.001).

No difference was observed in 25(OH)D3 concentration between patients with acute attack and those in attack-free period (p = 0.193). The distributions of FokI and TaqI genotypes were not significantly different between FMF patients and controls. There was a significant difference in the distribution of AA BsmI genotype between male FMF patients and male controls. Increased concentrations of triglycerides (p = 0.012) and decreased concentrations of high-density lipoprotein cholesterol [HDL-C] (p = 0.006) were found in FMF patients compared to controls. Although lower 25(OH)D3 concentrations were observed in FMF patients versus controls, no association was determined between FMF attack frequency and 25(OH)D3 concentrations. We showed that the AA genotype of BsmI polymorphism is associated with FMF in males but not in females. The effects of decreased HDL-C and increased triglyceride concentrations on cardiovascular events in FMF patients should be further investigated.

PMID: 28926322 DOI: 10.17305/bjbms.2017.2259

Created by admin. Last Modification: Wednesday September 20, 2017 14:37:53 UTC by admin. (Version 4)

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8450 FMF VDR.pdf PDF 2017 admin 20 Sep, 2017 14:35 942.84 Kb 5
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