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Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013

Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin d supplementation in patients with pulmonary tuberculosis'

BMC Infectious Diseases 2013, 13:22 doi:10.1186/1471-2334-13-22
Nawal Salahuddin, Farheen Ali, Zahra Hasan, Nisar Rao, Masooma Aqeel and Faisal Mahmood
Published: 19 January 2013

Background
Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host. The objectives of this study were to determine whether vitamin D supplementation to patients with tuberculosis (TB) could influence recovery.

Methods
Two hundred and fifty nine patients with pulmonary TB were randomized to receive either 600,000 IU of Intramuscular vitamin D3 or placebo for 2 doses. Assessments were performed at 4, 8 and 12 weeks. Early secreted and T cell activated 6 kDa (ESAT6) and Mycobacterium tuberculosis sonicate (MTBs) antigen induced whole blood stimulated IFN-g responses were measured at 0 and 12 weeks. Statistical comparisons between outcome variables at 0 and 12 weeks were performed using Student's t-test and Chi 2 tests.

Results
After 12 weeks, the vitamin D supplemented arm demonstrated significantly

  • greater mean weight gain (kg) + 3.75, (3.16 — 4.34)
    versus + 2.61 (95% CI 1.99 — 3.23) p 0.009 and
  • lesser residual disease by chest radiograph;
  • number of zones involved 1.35 v/s 1.82 p 0.004 (95% CI 0.15, 0.79) and
  • 50% or greater reduction in cavity size 106 (89.8%) v/s 111 (94.8%), p 0.035.

Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline 'Deficient' 25-hydroxyvitamin D serum levels (p 0.021).

Conclusions
Supplementation with high doses of vitamin D accelerated clinical, radiographic improvement in all TB patients and increased host immune activation in patients with baseline 'Deficient' serum vitamin D levels. These results suggest a therapeutic role for vitamin D in the treatment of TB.

Trial registration: ClinicalTrials.gov; No. NCT01130311; URL: clinicaltrials.gov


600,000 IU doses of vitamin D were given on day 0 and again on day 30 (from the PDF)
Reminder: TB sanitoriums, which gave direct sunlight access to TB patients, were found to be very userul a century ago.

 Download the PDF from VitaminDWiki.

See also VitaminDWiki

  • TB arrested by cod-liver oil (containing vitamin D) in 1848 3X better than other treatments at the time
    CLICK HERE if registered (free) for updated analysis of the 1848 study
  • All items in TB and vitamin D 84 items

Intervention AND TB in VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
2620 TB RCT - perhaps updated.pdf PDF 2013 admin 22 Jun, 2013 13:43 1.14 Mb 400
1973 TB RCT Jan 2013 red.pdf PDF admin 20 Jan, 2013 00:59 1.87 Mb 664
1972 TB semear.jpg admin 20 Jan, 2013 00:58 39.60 Kb 787
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