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Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017

The chemical disruption of human metabolism.

Toxicol Mech Methods. 2017 Sep;27(7):477-500. doi: 10.1080/15376516.2017.1323986. Epub 2017 Jun 7.
Genuis SJ1, Kyrillos E2.
1 Faculty of Medicine, University of Alberta , Edmonton , Alberta , Canada.
2 Department of Family Medicine , Faculty of Medicine, University of Ottawa , Ottawa , Ontario , Canada.

BACKGROUND:
Recent evidence highlights the reality of unprecedented human exposure to toxic chemical agents found throughout our environment - in our food and water supply, in the air we breathe, in the products we apply to our skin, in the medical and dental materials placed into our bodies, and even within the confines of the womb. With biomonitoring confirming the widespread bioaccumulation of myriad toxicants among population groups, expanding research continues to explore the pathobiological impact of these agents on human metabolism.

METHODS:
This review was prepared by assessing available medical and scientific literature from Medline as well as by reviewing several books, toxicology journals, government publications, and conference proceedings. The format of a traditional integrated review was chosen.

RESULTS:
Toxicant exposure and accrual has been linked to numerous biochemical and pathophysiological mechanisms of harm. Some toxicants effect metabolic disruption via multiple mechanisms.

CONCLUSIONS:
As a primary causative determinant of chronic disease, toxicant exposures induce metabolic disruption in myriad ways, which consequently result in varied clinical manifestations, which are then categorized by health providers into innumerable diagnoses. Chemical disruption of human metabolism has become an etiological determinant of much illness throughout the lifecycle, from neurodevelopmental abnormalities in-utero to dementia in the elderly.

One of the many tables in the PDF

Notes by VitaminDWiki are in italix

Drug or type of drug Possible deficiency
Antacids Folic acid, Calcium, Copper, Phosphate, Vitamin A, Vitamin B12
Antibiotics Vitamin K, L-leucine, Biotin
Atorvastatin Coenzyme Q10
Beta-adrenergic blocking agents Coenzyme Q10
Bile acid sequestrants Calcium, Carotenoids, Folic acid, Vitamins A, D, E, K, Zinc
Bisacodyl (Dulcolax, stimulant laxative) Potassium
Chemotherapy Magnesium, Vitamin B2, Taurine, and many other nutrients
Note: Vitamin D increases many Chemotherapies
Cholestyramine Carotenoids, Fat, Folic acid, Calcium, Iron, Magnesium, Phosphorus,
Zinc, Vitamin A, Vitamin B12, Vitamins A, D , E, K
Conjugated oestrogens (Premarin) Vitamin B6
Corticosteroids Calcium, DHEA, Magnesium, Melatonin, Potassium, Folic acid,
Vitamin B6, B12, C, D, K, E, Selenium, Zinc
Digitalis (Digoxin, Lanoxin, Digitoxin) Magnesium, Calcium, Sodium, Potassium
Diuretics Magnesium, Potassium, Zinc, Vitamin B1
L-dopa ( Levodopa, Dopar, Larodapa) Vitamin B6, Potassium
Edetate :Calcium disodium (EDTA) Calcium, Zinc
Furosemide (Frusemide, loop diuretic) Calcium, Magnesium, Potassium, Vitamin B1, Vitamins B6 and C
Heparin Vitamin D
Histamine H2-antagonists Iron, Zinc, Folic acid, Vitamin B12
Isoniazid (INH, Laniazid, Rifamate, Rimactane) Calcium, Folic acid, Magnesium, Vitamins B3, B6, B12, D , E, K
Losartan (Cozaar, angiotensin-II receptor antagonist) Calcium, Chloride, Magnesium, Potassium, Sodium, Phosphate
Metformin (Glucophage) Vitamin B9, B12
Methotrexate Calcium, Vitamin B9
Oral contraceptives Magnesium, Manganese, Zinc, Folic acid, Vitamins B1, B2, B3, B6, B12, C
Note: Many Oral contraceptives increase Vitamin D
Proton Pump Inhibitors Beta carotene, Vitamin B12, Calcium
Note:PPI may decrease Magnesium
Simvastatin (Zocor) Coenzyme Q10, Vitamin E, Beta carotene
Thiazide diuretics Magnesium, Potassium, Sodium, Zinc
Ventolin (Albuterol/Salbutamol/Proventil) Calcium, Magnesium, Phosphate, Potassium


Note: Does not consider Omega-3, Iodine, nor Boron

 Download the PDF from ResearchGate via VitaminDWiki


See also VitaminDWiki

Created by admin. Last Modification: Tuesday October 10, 2017 07:19:24 UTC by admin. (Version 13)

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8532 Chemical disruption of human metabolism-min.pdf PDF 2017 admin 09 Oct, 2017 20:35 957.72 Kb 25
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