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Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017

Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: a meta-analysis

Nephrologiy online: 13 July 2017, DOI: 10.1111/nep.13111
Fang Yin, Jing Liu, Ming-Xiu Fan, Xiao-Li Zhou, Xiao-Ling Zhang


Items in both categories Kidney and Vitamin D Receptor:

Items in both categories Diabetes and Vitamin D Receptor:

Items in both categories Diabetes and Kidney:

Vitamin D Receptor category has a summary table

If poor Vitamin D Receptor

Health Problem
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1Lumbar Disc Degeneration
3.1Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
2.8Osteoporosis if COPD
2.7Gastric Cancer
2.6Lupus in children
2.4Lung Cancer
2Diabetic Retinopathy
2 Wheezing/Asthma
2 Melanoma
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4 Rheumatoid arthritis
1.3Childhood asthma

Diabetic nephropathy (DN) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this study was to estimate the effect between Apa I, Bsm I, Fok I and Taq I polymorphisms of the vitamin D receptor (VDR) gene and DN susceptibility.

Eligible case–control studies published updated to March 2017 were searched. The odds ratio (OR) and 95% confident intervals (CI) were employed to calculate the strength of effect.

12 articles were finally screened out, including 3954 diabetic patients and 1248 healthy controls. When compared with the diabetic patients without nephropathy, our results found that only the Bsm I polymorphism was associated with increased risk of DN under the

  • allelic model (B vs. b: OR = 1.51, 95% CI = 1.03-2.20, P = 0.04) and
  • dominant model (BB + Bb vs. bb: OR = 1.52, 95% CI = 1.00-2.31, P = 0.05).

When compared with the healthy controls, our results showed that the Bsm I polymorphism was associated with the DN susceptibility under the

  • allelic model (B vs. b: OR = 1.80, 95% CI = 1.12-2.91, P = 0.02), the
  • homogeneous model (BB vs. bb: OR = 1.43, 95% CI = 1.03-1.98, P = 0.03), and the
  • domain model (BB + Bb vs. bb: OR = 1.80, 95% CI = 1.06-3.05, P = 0.03);

the Taq I variant was associated with increased risk of DN only under the heterogeneous model (Tt vs. tt: OR = 2.29, 95% CI = 1.04-5.03, P = 0.04).

Our results suggested that B allele, and BB + Bb genotypes of Bsm I variant, Tt genotype of Taq I variant might be risk factors for DN. Future researches are still needed to identify our results.

Created by admin. Last Modification: Friday July 14, 2017 01:15:15 UTC by admin. (Version 3)
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