The Association of Vitamin D Deficiency and Glucose Control Among Diabetic Patients
Saudi Pharmaceutical Journal, online 12 Sept. 2017, https://doi.org/10.1016/j.jsps.2017.09.001
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- 4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64% April 2010
Studies in both categories Diabetes and Dark Skin are listed here:
- Diabetic blacks – 80 percent had low vitamin D (less than 20 ng) a decade before – Sept 2017
- Diabetes is associated with low vitamin D in various races, but not blacks – Sept 2015
- Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- Diabetic glycation control is inversely related to Vitamin D in India – Feb 2015
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Dr. Holick video on vitamin D - March 2013
- African-Americans at high risk of obesity and diabetes - 2011
- Type 1 Diabetes associated with low vitamin D, especially in dark skinned youths – Dec 2012
- Diabetics with darker skin were more vitamin D deficient – May 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- Virtually all Native American children low on vitamin D and had indications of diabetes – Oct 2011
- Diabetic neuropathy and low vitamin D, especially in blacks - July 2011
- Studies linked low vitamin D and dark skin to Obesity, Diabetes, and heart – June 2011
- Not yet certain that vitamin D reduces cardiovascular and diabetes in blacks – Mar 2011
- Diabetes Statistics including more diabetes with darker skin – 2007
- Insulin resistance correlated with low vitamin D levels in Arab Americans – June 2010
- Insulin sensitivity associated with Vit D in A-A April 2010
- Vitamin D deficiency and insulin insensitivity in African Americans - 2010
Deficiency = < 20ng (many believe deficiency = < 30 ng and that optimal is > 40 ng)
To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes.
Research design and Method
We analyzed data collected from NHANES 2003-2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin D deficiency. We used a multivariate logistic regression model to predict the relationship between glucose control and vitamin D deficiency. We used race/ethnicity, BMI, age, gender, type of diabetic medication used, having health insurance or not, and comorbid conditions (hypertension, anemia, cholesterol, liver disease, and kidney disease) as control variables.
The study population included a total of 929 non-institutionalized, non-pregnant, diabetic adult persons. About 57% of patients with diabetes had a vitamin D deficiency. Blacks (non-Hispanic patients) with diabetes had the highest rate of vitamin D deficiency (79%). The unadjusted means of HbA1c were significantly different between diabetic patients with no vitamin D deficiency and those with a vitamin D deficiency (7.06% [54 mmol/L], 7.56 % [59 mmol/L], respectively, P<0.0001). Multivariate adjustment showed a small but not significant, increase in odds (11%) of having uncontrolled diabetes in patients with a vitamin D deficiency after adjustment for other factors.
Vitamin D deficiency is very common in patients with diabetes. We found no significant association between vitamin D level and glycemic control in patients with diabetes after adjustment for control variables.
Conclusion in PDF
In conclusion, vitamin D deficiency is more common in patients with diabetes. Therefore, monitoring of serum vitamin D level in diabetics is advised. Although we found that correcting the level of vitamin D is not likely to improve glycemic control, other studies suggested that vitamin D supplementation may help to reduce the development of other health risks such as bone diseases, cognitive impairment, and cardiovascular diseases.
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