Vitamin D Deficiency in Patients With Chronic Tension-Type Headache: A Case-Control Study
Headache: Journal of Head and Face Pain, First published: 3 May 2017, DOI: 10.1111/head.13096
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Metal Migraine No Migraine Ratio Cadmium 0.36 ug 0.09 ug 4X MORE if decrease Iron 0.97 ug 0.48 ug 2X MORE if decrease Lead 1.48 ug 0.78 ug 2X MORE if decrease Magnesium 10.6 ug 34.5 ug 3.5X LESS if increase Zinc 0.24 ug 5.77 ug 24X LESS if increase
Reviewed at Vitamin D Council
Sanjay Prakash DM (Neurology), drprakashs at yahoo.co.in, Chaturbhuj Rathore DM (Neurology),
Prayag Makwana DM (Neurology), Ankit Dave DM (Neurology),
Hemant Joshi DM (Neurology),Haresh Parekh DM (Neurology)
Objective: To see the interrelation between chronic tension-type headache (CTTH) and serum vitamin D levels.
Background: Several studies have suggested an association between chronic pain and vitamin D deficiency. Anecdotal evidence suggests that vitamin D deficiency may be associated with tension-type headache and migraine.
Methods: This case-control study was carried out to examine the association between CTTH and serum 25-hydroxy vitamin (25(OH) D) levels. One hundred consecutive adult (>18 years) patients with CTTH and 100 matched healthy controls were enrolled.
Results: The serum 25(OH) D levels were significantly lower in CTTH patients than in the controls (14.7 vs 27.4 ng/mL).
The prevalence of vitamin D deficiency (serum 25 (OH) D < 20 ng/mL) was greater in patients with CTTH (71% vs 25%).
CTTH patients had a significantly high prevalence of
- musculoskeletal pain (79% vs 57%),
- muscle weakness (29% vs 10%),
- muscle tenderness score (7.5 vs 1.9), and
- bone tenderness score (3.0 vs 0.8) in comparison to controls.
CTTH patients with vitamin D deficient group (<20 ng/mL) had a higher prevalence of
- musculoskeletal pain (58% vs 31%),
- muscle weakness (38% vs 7%),
- muscle and bone tenderness score,
- associated fatigue (44% vs 17%) and
- more prolonged course (15.5 months vs 11.2 months).
A strong positive correlation was noted between serum vitamin D levels and total muscle tenderness score (R2 = 0. 7365) and total bone tenderness score (R2 = 0. 6293).
Conclusion: Decreased serum 25(OHD) concentration was associated with CTTH. Intervention studies are required to find out if supplementation of vitamin D is effective in patients with CTTH.
“Ultimately we're going to need a large-scale vitamin D intervention study to look for outcomes.”
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