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Children with low vitamin D were 1.8 X more likely to have poor arteries 27 years later – Feb 2015

Childhood 25-OH Vitamin D Levels and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study

The Journal of Clinical Endocrinology & Metabolism DOI: http://dx.doi.org/10.1210/jc.2014-3944
Received: October 28, 2014, Accepted: January 07, 2015. Published Online: February 10, 2015
Markus Juonala, Atte Voipio, Katja Pahkala, Jorma S. A. Viikari, Vera Mikkilä, Mika Kähönen, Nina Hutri-Kähönen, Antti Jula, David Burgner, Matthew A. Sabin, Jukka Marniemi, Britt-Marie Loo, Tomi Laitinen, Eero Jokinen, Leena Taittonen, Costan G. Magnussen, Olli T. Raitakari

Image

Context:
Low vitamin D levels in adulthood have been associated with cardiovascular disease.

Objective:
To investigate if low vitamin D levels in childhood are related with increased carotid artery intima-media thickness (IMT) in adulthood.

Design, Setting, and Participants:
The analyses included 2148 subjects from the Cardiovascular Risk in Young Finns Study, aged 3–18 years at baseline (in 1980). Subjects were re-examined at age 30–45 years (in 2007). Childhood levels of 25-hydroxy-vitamin D were measured from stored serum in 2010.

Main Outcome Measure:
The carotid artery IMT from 2007 was used.

Results:
When adjusted for age, sex, and childhood risk factors, continuous data of childhood 25-OH vitamin was inversely associated with adulthood carotid IMT levels among females (β ± SE −0.006 ± 0.003, P = 0.03), but not among males (0.001 ± 0.004, P = 0.88). Children with 25-OH vitamin D levels in the lowest quartile (<40 nmol/L) had significantly increased odds of having high-risk IMT (highest decile of common carotid or carotid bulb IMT or carotid plaque) as adults, in analyses adjusted for age, sex and either childhood risk factors (odds ratio 1.70 [95 % CI 1.15–2.31], P = 0.0007) or adult risk factors, including adult vitamin D levels (odds ratio 1.80 [1.30–2.48], P = 0.0004). In sex-specific analyses, these associations were significant both in females and males (P always <0.05). In sensitivity analyses, those with childhood vitamin D levels in the lowest quintile (<37 nmol/L), gave similar results to those using a quartile cut-point.

Conclusions:
Low 25-OH vitamin D levels in childhood were associated with increased carotid IMT in adulthood.

 Download the PDF from VitaminDWiki.


Interesting: An 8 year delay from measurement time till publication

Attached files

ID Name Comment Uploaded Size Downloads
5038 Children arteries.jpg admin 11 Feb, 2015 28.79 Kb 804
5037 Children arteries.pdf admin 11 Feb, 2015 355.52 Kb 612