Vitamin D has been shown to enhance many types of Chemotherapy
So, be careful about taking vitamin D IF your doctor is unwilling to reduce the amount of chemo to be given.
Chemo dosages were established for the majority of people who have low levels of vitamin D in their blood.
It appears that if you take the normal Chemo dose AND a good level of vitamin D in your blood you will get 2X the impact.
The impact varies with the type of Chemo, suggest that you search PubMed for "name of chemo" "Vitamin D"
Chart by VitaminDwiki
CLICK HERE for Chemotherapy and vitamin D - review 2010 PDF
they do not seem concerned
Study Shows Benefits of Adding High-Dose Calcitriol to Chemotherapy for Advanced Prostate Cancer: Presented at ASCO - 2002
Calcitriol May Safely Double Effectiveness of Taxotere Treatment
ORLANDO, FL — May 21, 2002 — The addition of high-dose calcitriol to weekly treatment with the chemotherapy agent docetaxel (Taxotere®) appears to improve the therapeutic response in men with hormone-refractory prostate cancer without compromising safety, according to results reported at the 38th Annual Meeting of the American Society of Clinical Oncology (ASCO). Calcitriol is the active form of vitamin D.
Data from a phase II clinical trial suggest as much as twice the efficacy with the docetaxel/calcitriol combination than docetaxel alone, as measured by prostate-specific antigen (PSA) response rate. The study showed that 81 percent of patients treated with the combination regimen cut their PSA levels by more than half. Studies of docetaxel without calcitriol have reported a 42 percent PSA response rate overall. PSA is a substance produced within the prostate gland, and a high PSA level may indicate the presence of cancer. In patients with advanced prostate cancer, PSA correlates with the amount of cancer in the body.
Popular Chemotherapy drugs
Wonder how many chemo drugs vitamin D interacts with
|Carboplatin (Paraplatin)||cancers of the ovary, head and neck, and lung|
|Cisplatin (Platinol, Platinol-AQ)||cancers of the bladder, ovary, and testicles|
|Cyclophosphamide (Cytoxan, Neosar)||lymphoma, breast cancer, and ovarian carcinoma|
|Docetaxel (Taxotere)||breast cancer, lung, and prostate|
|Doxorubicin (Adriamycin)||breast cancer, lymphoma, and multiple myeloma|
|Erlotinib (Tarceva)||non small cell lung cancer|
|Etoposide (VePesid)||cancers of the lung, testicles, leukemia, and lymphoma|
|Fluorouracil (5-FU)||cancers of the colon, breast, stomach, and head and neck|
|Gemcitabine (Gemzar)||cancers of the pancreas, breast, ovary, and lung|
|imatinib mesylate (Gleevec)|| chronic myelogenous leukemia (CML) |
and gastrointestinal stromal tumor (GIST)
|Irinotecan (Camptosar)||cancers of the colon and rectum|
|Methotrexate (Folex, Mexate, Amethopterin)||cancers of the breast, lung, blood, bone, and lymph system|
|Paclitaxel (Taxol, Abraxane)||cancers of the breast, ovary, and lung|
|Sorafinib (Nexavar)||advanced kidney cancer|
|Sunitinib (Sutent)||gastrointestinal stromal tumor (GIST) and kidney cancer|
|Topotecan (Hycamtin)||cancers of the ovary and lung|
|Vincristine (Oncovin, Vincasar PFS)||leukemia and lymphoma|
|Vinblastine (Velban)||lymphoma and cancers of the testis and head and neck|
Vitamin D in combination cancer treatment.
Cancer. 2010 Jul 15;1:101-7.
Ma Y, Trump DL, Johnson CS.
1. Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1?, 25-dihydroxycholecalciferol (calcitriol) also has broad spectrum anti-tumor activities as supported by numerous epidemiological and experimental studies.
Calcitriol potentiates the anti-tumor activities of multiple chemotherapeutics agents including DNA-damaging agents cisplatin, carboplatin and doxorubicin; antimetabolites 5-fluorouracil, cytarabine, hydroxyurea, cytarabine and gemcitabine; and microtubule-disturbing agents paclitaxel and docetaxel.
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms.
Calcitriol enhances the cytotoxic effects of gamma irradiation and certain antioxidants and naturally derived compounds.
Inhibition of calcitriol metabolism by 24-hydroxylase promotes growth inhibition effect of calcitriol.
Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.
Several trials have demonstrated that safe and feasible to administer high doses of calcitriol through intermittent regimen.
Further well designed clinical trials should be conducted to better understand the role of calcitriol in cancer therapy. PMID: 20842231
Chemotherapy toxicity not associated with vitamin D levels – June 2012
The relationship between vitamin D and chemotherapy-induced toxicity - a pilot study.
Kitchen D, Hughes B, Gill I, O'Brien M, Rumbles S, Ellis P, Harper P, Stebbing J, Rohatgi N.
Br J Cancer. 2012 Jun 26;107(1):158-60. doi: 10.1038/bjc.2012.194. Epub 2012 May 15.
Leaders in Oncology Care (LOC), 95 Harley Street, London W1G 6AF, UK. dkitchen at theloc.com
There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further.
From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin.
RESULTS: A total of 241 (2% of the total cohort) individuals entered the toxicity analysis.
We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78).
CONCLUSION: This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.
Cancer Chemotherapy and vitamin D – Review March 2013 has the following chart
PDF is attached at the bottom of this page
See also VitaminDWiki
- All items in category After Cancer Diagnosis
- Search VitaminDWiki for Chemotherapy 606 items as of Sept 2017
- Chemo drug (Nitrogen Mustard in this study) side effects minimized by vitamin D (mice) – March 2015
- Chemotherapy (cisplatin) and vitamin D synergistically stop stomach cancer – Feb 2014
- Vitamin D appears to both prevent and treat various cancers – Mar 2011
- Is vitamin D the only supplement which consistently helps cancer survivors – Aug 2010
- Cancer survivors helped with lots of Vitamin D – Aug 2010
- Metastatic Cancer is maybe reduced by vitamin D - 5 articles
- Vitamin D3 sensitizes breast cancer to radiation treatment - increasing cancer cell death – May 2010
- Vitamin D reduces lung damage due to radiotherapy – Oct 2011
- Vitamin D and breast cancer radiation
- If vitamin D levels were not changed, toxicity to chemotherapy did not vary with levels – May 2012
- Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011
- Breast Cancer Chemotherapy initially decreases vitamin D levels – May 2012
- Breast cancer chemotherapy benefits from highest vitamin D levels – June 2014
- If vitamin D levels were not changed, toxicity to chemotherapy did not vary with levels – May 2012
- Vitamin D levels dropped 3 ng during cancer chemotherapy – May 2012
- Cancer Chemotherapy and vitamin D – Review March 2013
- Hypothesis – Chemotherapy can be aided by Vitamin D – March 2016
- Less radiation therapy needed if have more vitamin D (lung cancer in lab) – March 2017
- Chemotherapy might be augmented with Vitamin D – Jan 2017
See also web
- PubMed Search for chemotherapy "vitamin d" 13,563 items Nov 2017
- PubMed "cancer treatment" "vitamin d" 174 items Nov 2017
- The beneficial role of vitamin D and its analogs in cancer treatment and prevention 2010
- Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology 2010 PDF attached to this page
- US Clinical Trials for chemotherapy "vitamin d" 51 as of Sept 2017
- US Clinical Trials for chemotherapy INTERVENTION "vitamin d" 44 items Nov 2017, such as
- Effectiveness of High Dose Vitamin D Supplementation in Stage III Colorectal Cancer - study completion 2022
- Vit D3 and Omega 3 in Chemo Induced Neuropathy - study completion Nov 2016
- Cholecalciferol in Treating Patients With Acute Myeloid Leukemia Undergoing Intensive Induction Chemotherapy - study completion June 2015
- Study of Vitamin D Supplementation Tailored to Vitamin D Deficiency in Breast Cancer Patients (VITACAL) 100,000 IU at intervals depending on initial deficiency
- High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and Bevacizumab as First-Line Therapy For Metastatic Colorectal Cancer
- Study of Vitamin D in Untreated Metastatic Colorectal Cancer (8,000 IU)
- Vitamin D deficiency in oncology patients--an ignored condition: impact on hypocalcemia and quality of life Oct 2012
98% on chemotherapy has less than 30 ng of vitamin D
- Vitamin D levels in patients of acute leukemia before and after remission-induction therapy Jan 2013 PDF at bottom of this page
- Keeping Your Hair in Chemo NYT March 2015
Freeze scalp during chemo treatments - no mention that vitamin D also preserves hair during chemo
Update - Nov 2017
Googled: chemotherapy "vitamin d" - first entry is this VitaminDWiki page
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Antioxidant supplements such as co enzyme Q10, selenium and the vitamins A, C and E can help to prevent cell damage
- VitaminDWiki comment - so Chemo doctors recommend NOT taking them!!
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Treatment can last for anywhere from 3 to 6 months. During that time, you would be considered to be immunocompromised — not as able to fight infection. After finishing chemotherapy treatment, it can take anywhere from about 21 to 28 days for your immune system to recover.
- VitaminDWiki Comment: Even if you wait until chemo is done Vitamin D can probably help the immune system recover
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Oct 2, 2008 - The odds of having severe vitamin D deficiency (25-OH vitamin D≤15 ng/ml) in a patient receiving chemotherapy was fourfold higher than a patient with colorectal cancer who never received chemotherapy or completed chemotherapy at least 3 months prior to their vitamin D assay.
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- 2017 - In the patients who received chemotherapy (45% ), those with sufficient vitamin D levels had a statistically longer survival than those with deficient levels (p<0.002). Also the patients with sufficient levels, they were more likely to complete the 6 months of chemotherapy than those with deficient levels (p<0.006)
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The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study - June 2012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389405/  Download the PDF from VitaminDWiki
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- In a laboratory study, vitamin D3 was found to increase breast cancer cell death caused by radiotherapy from approximately 30% to 75%.
- A 2016 study of 1,666 women in California found that higher levels of vitamin D at diagnosis were associated with improved survival, especially among premenopausal women.
- A prospective study which used stored blood of breast cancer patients to measure Vitamin D levels found that women with deficient vitamin D levels had a significantly increased risk of distant recurrence and death compared with those with sufficient levels. The authors concluded that vitamin D deficiency may be associated with poor outcomes in breast cancer.
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Vitamin D may increase survival for breast cancer patients
https://www.medicalnewstoday.com/articles/314017.php Nov 2016
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Appropriate vitamin D loading regimen for patients with advanced lung cancer - Oct 2016
20,000 IU a day for 14 days was not enough- full free PDF online
List of Cancer Chemotherapy Drugs 213 drugs as of Nov 2017
Cheno is a huge source of revenue to bigpharma Wikipedia
- VitaminDWiki comment -A patient needing less Chemo (due to Vitamin D) results in:
- less income for the hospital: which is a function of cost of chemo and reduced days in hospital
- Doctors/hospitals also get a large income from use of Chem drugs - they buy wholesale but bill retail
Thus often getting an additional income of $2,000/patient/month
We can anticipate lots of resistance to reducing chemo dose sizes as a result of having a good level of Vitamin D
VitaminDWiki recommends considering gut-friendly forms of vitamin D during chemotherapy
Chemotherapy/Radiation Therapy often upsets digestion Wikipedia
There are several forms of vitamin D for people with poor digestion
- Bio-emulsified drops doubled vitamin D levels – Dec 2010
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- People with poor guts getting nutrition via IV had poor oral Vitamin D bio-availability – May 2017
- Getting Vitamin D into your body has the following chart
Omega-3 looks promising to reduce/offset chemo and radiation therapy
- Breast cancer and Omega-3 – perhaps prevention and augment treatment – Aug 2017
- Omega-3 prevents and treats several cancers – Sept 2017 interactive display
- Omega-3 should help Pancreatic Cancer is 5 ways – June 2017 behind a $95 paywall
- Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018 - probably no results published until 2020
Stock up on Vitamin D before surgery or at least before Chemo (provided doctor adjusts the chemo/radiation doses)
For many people 400,000 IU of vitamin D will be sufficient to get a good level (Some will need 2X or 3X more)
Days IU/day 40 days 10,000 IU 8 days 50,000 IU 2 days 200,000 IU
Possible beneifts of having a good level of vitamin D before chemo starts
assuming that chemo dose is reduced
Less hair lost
Less recurrence of cancer
Less spread of cancer
Less bruising, infection
Less weight gain
Less peripheral neuropathy
Less hearing loss
Less reduction in fertility
Fewer bone problems
Fewer heart problems
Fewer mouth sores
What if a chemo drug is amplfied by Vitamin D more than 2X?
Note: Currently no chemo drug is known to be amplified by vitamin D by more than 2X
But, if chemo dose for the drug is reduced by only 2X the resulting chemo drug + Vitamin D could potentially be deadly
Wonder if there is any data on Vitamin D levels when taking many chemo drugs
Kaiser, Medicare, VA, etc.
l =http://is.gd/chemoDThis page is in the following categories (# of items in each category)Interactions with Vitamin D 77 Cancer - after diagnosis 58
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