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Chemotherapy might be amplified by vitamin D

Vitamin D has been shown to enhance many types of Chemotherapy

So, be careful about taking vitamin D IF your doctor is unwilling to reduce the amount of chemo to be given.
Chemo dosages were established for the majority of people who have low levels of vitamin D in their blood.
It appears that if you take the normal Chemo dose AND a good level of vitamin D in your blood you will get 2X the impact.
The impact varies with the type of Chemo, suggest that you search PubMed for "name of chemo" "Vitamin D"


Chart by VitaminDwiki
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=396

Click here for 2017 update


CLICK HERE for Chemotherapy and vitamin D - review 2010 PDF
they do not seem concerned


Study Shows Benefits of Adding High-Dose Calcitriol to Chemotherapy for Advanced Prostate Cancer: Presented at ASCO - 2002

Calcitriol May Safely Double Effectiveness of Taxotere Treatment

ORLANDO, FL — May 21, 2002 — The addition of high-dose calcitriol to weekly treatment with the chemotherapy agent docetaxel (Taxotere®) appears to improve the therapeutic response in men with hormone-refractory prostate cancer without compromising safety, according to results reported at the 38th Annual Meeting of the American Society of Clinical Oncology (ASCO). Calcitriol is the active form of vitamin D.

Data from a phase II clinical trial suggest as much as twice the efficacy with the docetaxel/calcitriol combination than docetaxel alone, as measured by prostate-specific antigen (PSA) response rate. The study showed that 81 percent of patients treated with the combination regimen cut their PSA levels by more than half. Studies of docetaxel without calcitriol have reported a 42 percent PSA response rate overall. PSA is a substance produced within the prostate gland, and a high PSA level may indicate the presence of cancer. In patients with advanced prostate cancer, PSA correlates with the amount of cancer in the body.


Wonder how many chemo drugs vitamin D interacts with

from Caring4Cancer

Carboplatin (Paraplatin) cancers of the ovary, head and neck, and lung
Cisplatin (Platinol, Platinol-AQ) cancers of the bladder, ovary, and testicles
Cyclophosphamide (Cytoxan, Neosar) lymphoma, breast cancer, and ovarian carcinoma
Docetaxel (Taxotere) breast cancer, lung, and prostate
Doxorubicin (Adriamycin) breast cancer, lymphoma, and multiple myeloma
Erlotinib (Tarceva) non small cell lung cancer
Etoposide (VePesid) cancers of the lung, testicles, leukemia, and lymphoma
Fluorouracil (5-FU) cancers of the colon, breast, stomach, and head and neck
Gemcitabine (Gemzar) cancers of the pancreas, breast, ovary, and lung
imatinib mesylate (Gleevec) chronic myelogenous leukemia (CML)
and gastrointestinal stromal tumor (GIST)
Irinotecan (Camptosar) cancers of the colon and rectum
Methotrexate (Folex, Mexate, Amethopterin) cancers of the breast, lung, blood, bone, and lymph system
Paclitaxel (Taxol, Abraxane) cancers of the breast, ovary, and lung
Sorafinib (Nexavar) advanced kidney cancer
Sunitinib (Sutent) gastrointestinal stromal tumor (GIST) and kidney cancer
Topotecan (Hycamtin) cancers of the ovary and lung
Vincristine (Oncovin, Vincasar PFS) leukemia and lymphoma
Vinblastine (Velban) lymphoma and cancers of the testis and head and neck

Vitamin D in combination cancer treatment.

Cancer. 2010 Jul 15;1:101-7.
Ma Y, Trump DL, Johnson CS.
1. Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1?, 25-dihydroxycholecalciferol (calcitriol) also has broad spectrum anti-tumor activities as supported by numerous epidemiological and experimental studies.

Calcitriol potentiates the anti-tumor activities of multiple chemotherapeutics agents including DNA-damaging agents cisplatin, carboplatin and doxorubicin; antimetabolites 5-fluorouracil, cytarabine, hydroxyurea, cytarabine and gemcitabine; and microtubule-disturbing agents paclitaxel and docetaxel.

Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms.

Calcitriol enhances the cytotoxic effects of gamma irradiation and certain antioxidants and naturally derived compounds.
Inhibition of calcitriol metabolism by 24-hydroxylase promotes growth inhibition effect of calcitriol.
Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.
Several trials have demonstrated that safe and feasible to administer high doses of calcitriol through intermittent regimen.
Further well designed clinical trials should be conducted to better understand the role of calcitriol in cancer therapy. PMID: 20842231


Chemotherapy toxicity not associated with vitamin D levels – June 2012

The relationship between vitamin D and chemotherapy-induced toxicity - a pilot study.
Kitchen D, Hughes B, Gill I, O'Brien M, Rumbles S, Ellis P, Harper P, Stebbing J, Rohatgi N.
Br J Cancer. 2012 Jun 26;107(1):158-60. doi: 10.1038/bjc.2012.194. Epub 2012 May 15.
Leaders in Oncology Care (LOC), 95 Harley Street, London W1G 6AF, UK. dkitchen at theloc.com

BACKGROUND:
There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further.

METHODS:
From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin.

RESULTS: A total of 241 (2% of the total cohort) individuals entered the toxicity analysis.
We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78).

CONCLUSION: This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.

PMID: 22588559


Cancer Chemotherapy and vitamin D – Review March 2013 has the following chart

Image
PDF is attached at the bottom of this page


See also VitaminDWiki

See also web

  • Keeping Your Hair in Chemo NYT March 2015
    Freeze scalp during chemo treatments - no mention that vitamin D also preserves hair during chemo

Update - Nov 2017

Googled: chemotherapy "vitamin d" - first entry is this VitaminDWiki page
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Antioxidant supplements such as co enzyme Q10, selenium and the vitamins A, C and E can help to prevent cell damage
- VitaminDWiki comment - so Chemo doctors recommend NOT taking them!!
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Treatment can last for anywhere from 3 to 6 months. During that time, you would be considered to be immunocompromised — not as able to fight infection. After finishing chemotherapy treatment, it can take anywhere from about 21 to 28 days for your immune system to recover.
http://www.breastcancer.org/tips/immune/cancer/chemo
- VitaminDWiki Comment: Even if you wait until chemo is done Vitamin D can probably help the immune system recover
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Oct 2, 2008 - The odds of having severe vitamin D deficiency (25-OH vitamin D≤15 ng/ml) in a patient receiving chemotherapy was fourfold higher than a patient with colorectal cancer who never received chemotherapy or completed chemotherapy at least 3 months prior to their vitamin D assay.
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- ‎2017 - In the patients who received chemotherapy (45% ), those with sufficient vitamin D levels had a statistically longer survival than those with deficient levels (p<0.002). Also the patients with sufficient levels, they were more likely to complete the 6 months of chemotherapy than those with deficient levels (p<0.006)
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The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study - June 2012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389405/    Download the PDF from VitaminDWiki
Image
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  • In a laboratory study, vitamin D3 was found to increase breast cancer cell death caused by radiotherapy from approximately 30% to 75%.
  • A 2016 study of 1,666 women in California found that higher levels of vitamin D at diagnosis were associated with improved survival, especially among premenopausal women.
  • A prospective study which used stored blood of breast cancer patients to measure Vitamin D levels found that women with deficient vitamin D levels had a significantly increased risk of distant recurrence and death compared with those with sufficient levels. The authors concluded that vitamin D deficiency may be associated with poor outcomes in breast cancer.
    http://foodforbreastcancer.com/articles/how-important-is-vitamin-d-before-and-after-breast-cancer-diagnosis%3F

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Vitamin D may increase survival for breast cancer patients
https://www.medicalnewstoday.com/articles/314017.php Nov 2016
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Appropriate vitamin D loading regimen for patients with advanced lung cancer - Oct 2016
20,000 IU a day for 14 days was not enough- full free PDF online
https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0203-8
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List of Cancer Chemotherapy Drugs 213 drugs as of Nov 2017
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Cheno is a huge source of revenue to bigpharma Wikipedia
- VitaminDWiki comment -A patient needing less Chemo (due to Vitamin D) results in:

  • less income for the hospital: which is a function of cost of chemo and reduced days in hospital
  • Doctors/hospitals also get a large income from use of Chem drugs - they buy wholesale but bill retail
    Thus often getting an additional income of $2,000/patient/month
    We can anticipate lots of resistance to reducing chemo dose sizes as a result of having a good level of Vitamin D

VitaminDWiki recommends considering gut-friendly forms of vitamin D during chemotherapy

Chemotherapy/Radiation Therapy often upsets digestion Wikipedia
There are several forms of vitamin D for people with poor digestion

Image


Omega-3 looks promising to reduce/offset chemo and radiation therapy

Stock up on Vitamin D before surgery or at least before Chemo (provided doctor adjusts the chemo/radiation doses)

For many people 400,000 IU of vitamin D will be sufficient to get a good level (Some will need 2X or 3X more)

Days IU/day
40 days 10,000 IU
8 days 50,000 IU
2 days200,000 IU

Possible beneifts of having a good level of vitamin D before chemo starts
   assuming that chemo dose is reduced

Less hair lost
Less nauseated
Less fatigue
Less recurrence of cancer
Less spread of cancer
Less chemo-brain
Less bruising, infection
Less weight gain
Less constipation/diarrhea
Less anemia
Less peripheral neuropathy
Less hearing loss
Less reduction in fertility
Fewer bone problems
Fewer heart problems
Fewer mouth sores
Live longer

Nice list of Chemo side effects


What if a chemo drug is amplfied by Vitamin D more than 2X?

Note: Currently no chemo drug is known to be amplified by vitamin D by more than 2X
But, if chemo dose for the drug is reduced by only 2X the resulting chemo drug + Vitamin D could potentially be deadly
Wonder if there is any data on Vitamin D levels when taking many chemo drugs
   Kaiser, Medicare, VA, etc.


url =http://is.gd/chemoD

Attached files

ID Name Comment Uploaded Size Downloads
8769 Chemo Vitamin D - 2012.pdf admin 19 Nov, 2017 21:32 143.14 Kb 15
8768 Chemo Vitamin D - 2012.jpg admin 19 Nov, 2017 21:32 83.85 Kb 308
3497 Vitamin D levels in patients of acute leukemia.pdf PDF - 2013 admin 08 Jan, 2014 13:14 1.06 Mb 819
3329 Cancer drugs T1.gif admin 29 Nov, 2013 01:20 58.71 Kb 13251
3328 cancer drugs.pdf PDF - 2013 admin 29 Nov, 2013 01:19 617.25 Kb 733
932 Vitamin D and Oncology - 2010.pdf PDF admin 14 Dec, 2011 03:51 275.88 Kb 1111
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