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Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017

Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators.

Curr Vasc Pharmacol. 2017 Aug 21. doi: 10.2174/1570161115666170821154841. [Epub ahead of print]
Stokic E1, Romani A2, Ilincic B1, Kupusinac A3, Stosic Z1, Isenovic ER4.
1 Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad. Serbia.
2 Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland. United States.
3 Faculty of Technical Sciences, University of Novi Sad, Novi Sad. Serbia.
4 Laboratory for Molecular Genetics and Radiobiology, Institute Vinca, University of Belgrade, Belgrade. Serbia.

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BACKGROUND:
Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and cardiovascular disease (CVD).

OBJECTIVE:
We examined the frequency of concomitant deficit of magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects.

METHOD:
Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i.e. body mass index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators [insulin resistance (Homeostatic Model Assessment for insulin resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status [i.e. total serum Mg concentration (TMg), chronic latent Mg deficiency (CLMD) - 0.75-0.85 mmol/L], vitamin D status [i.e. serum concentration of 25-hydroxyvitamin D (25(OH)D), vitamin D deficiency <50 nmol/l] were assessed.

RESULTS:
Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH)D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg ˂0.85 mmol/L), a negative linear coefficient was found between 25(OH)D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg ≥0.85 mmol/L).

CONCLUSION:
CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.

PMID: 28828979 DOI: 10.2174/1570161115666170821154841

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